Table 3.

Association of plasma vitamin D concentration with prostate cancer risk: SELECT

Model	Vitamin D (nmol/L)	N (case)	N (cohort)	HR	95% CI	P
Overall prostate cancer
Model 1^a	<37.5	199	464	1.00
	37.5–<50	259	470	1.08	0.83–1.41	0.572
	50–<75	550	1,070	0.89	0.70–1.12	0.328
	≥75	723	1,199	0.98	0.78–1.24	0.897
Model 2^a,^b	<37.5	183	426	1.00
	37.5–<50	239	475	0.90	0.68–1.18	0.444
	50–<75	588	1,123	0.85	0.67–1.09	0.200
	≥75	721	1,179	0.96	0.75–1.23	0.763
Model 3^a,^b,^c	<44.1	308	639	1.00
	44.1–<58.2	318	645	0.83	0.66–1.03	0.092
	58.2–<72.9	320	638	0.74	0.59–0.92	0.008
	72.9–<90.7	363	641	0.86	0.69–1.07	0.181
	≥90.7	422	640	0.98	0.78–1.21	0.823
Gleason 2–6 prostate cancer
Model 1^a	<37.5	107	464	1.00
	37.5–<50	157	470	1.20	0.87–1.65	0.269
	50–<75	309	1,070	0.90	0.67–1.20	0.454
	≥75	441	1,199	1.05	0.79–1.40	0.738
Model 2^a,^b	<37.5	97	426	1.00
	37.5–<50	137	475	0.94	0.67–1.32	0.732
	50–<75	345	1,123	0.89	0.66–1.21	0.467
	≥75	435	1,179	1.01	0.75–1.37	0.943
Model 3^a,^b,^c	<44.1	167	639	1.00
	44.1–<58.2	190	645	0.87	0.66–1.14	0.302
	58.2–<72.9	190	638	0.76	0.58–1.00	0.048
	72.9–<90.7	210	641	0.86	0.66–1.13	0.276
	≥90.7	257	640	1.01	0.77–1.31	0.957
Gleason 7–10 prostate cancer
Model 1^a	<37.5	67	464	1.00
	37.5–<50	72	470	0.85	0.56–1.28	0.435
	50–<75	157	1,070	0.75	0.52–1.07	0.107
	≥75	206	1,199	0.86	0.60–1.22	0.402
Model 2^a,^b	<37.5	60	426	1.00
	37.5–<50	73	475	0.86	0.56–1.31	0.477
	50–<75	163	1,123	0.75	0.51–1.09	0.132
	≥75	206	1,179	0.91	0.63–1.33	0.642
Model 3^a,^b,^c	<44.1	104	639	1.00
	44.1–<58.2	81	645	0.63	0.45–0.90	0.010
	58.2–<72.9	91	638	0.66	0.47–0.92	0.016
	72.9–<90.7	107	641	0.79	0.56–1.10	0.165
	≥90.7	119	640	0.88	0.63–1.22	0.436
Gleason 8–10 prostate cancer
Model 1^a	<37.5	16	464	1.00
	37.5–<50	14	470	0.71	0.32–1.58	0.406
	50–<75	27	1,070	0.41	0.20–0.83	0.013
	≥75	47	1,199	0.70	0.36–1.36	0.288
Model 2^a,^b	<37.5	12	426	1.00
	37.5–<50	15	475	0.96	0.41–2.25	0.926
	50–<75	29	1,123	0.55	0.25–1.20	0.131
	≥75	48	1,179	0.95	0.45–2.02	0.894
Model 3^a,^b,^c	<44.1	20	639	1.00
	44.1–<58.2	20	645	0.68	0.34–1.34	0.267
	58.2–<72.9	13	638	0.36	0.16–0.78	0.010
	72.9–<90.7	27	641	0.85	0.44–1.65	0.630
	≥90.7	24	640	0.78	0.40–1.54	0.477

↵^aHRs adjusted for age and race (though matching) and family history of prostate cancer, BMI, baseline diabetes, and SELECT treatment arm (as covariates).
↵^bVitamin D values adjusted for month of serum sample.
↵^cQuintiles are calculated based on the distribution among the cohort.