Table 1.

Summary of findings from studies that measured protein expression of selected EMT markers and patient outcomes in colorectal cancer tumorsa

Percent positivebSurvivalEffect estimates
Marker# StudiesRange# Studies# With difference by marker status# Studies# With effect on outcomes
β-catenin542%–90%2010
Cytokeratins29%–85%2110
E-cadherin1529%–92%4331
Fibronectin00000
Integrins219%–88%1111
N-cadherin20%–44%0010
Slug230%–37%2111
Snail540%–79%322Mixed
TGFβ282%–89%1000
Twist448%–100%113Mixed
Vimentin40%–49%0000
ZEB1129%1100
ZEB2248%–90%111Mixed

NOTE: Mixed, at least one study of a given marker reported both statistically significant and nonsignificant estimates of the effect of marker expression levels on outcomes.

  • aThe number of studies under percentage of tumors with positive marker expression, survival, or effect estimates refers to the number of studies that reported values for that measurement for a given marker.

  • bDefinitions of positive marker expression in a tumor generally varied across multiple studies of a given marker.