Multivariate modeling performed in included studies
| First author | EMT markers examined | Type of regression | Adjustment covariates |
|---|---|---|---|
| Bates et al. (45) | Integrin α-v-β-6 | Cox | Age, sex, tumor type (colon vs. rectal), tumor stage |
| Bellovin et al. (34) | E-cadherin | Cox | Age, sex, tumor stage, lymph node status |
| Bellovin et al. (35) | E-cadherin | Cox | Age, sex, tumor stage, lymph node status |
| Fan et al. (20) | E-cadherin, N-cadherin, Twist, Snail, β-catenin | Logistic | Support vector machine, tumor stage, CEA, CA19-9, CA125 |
| Fan et al. (36) | E-cadherin, Twist, Snail | Logistic | Age, sex, histologic grade, tumor class |
| Fujikawa et al. (37) | E-cadherin | Cox | Age, pathologic T category, lymph node metastasis |
| Gomez et al. (48) | Twist, Slug (RNA only for both) | Cox | Age, sex, lymph node metastasis status, tumor stage, treatment protocol (e.g., chemo vs. surgery) |
| Harbaum et al. (30) | Cytokeratin-7, E-cadherin | Cox | Age, sex, T classification, N classification, tumor grade |
| Kahlert et al. (50) | ZEB2 | Cox | Age, sex, tumor stage, grade, type of resection (curative vs. noncurative), microsatellite stability, KRAS mutation status |
| Kevans et al. (23) | E-cadherin, β-catenin | Cox | Age, sex, T-stage, tumor site, tumor differentiation, tumor budding, lymphovascular invasion, neural invasion, microsatellite status |
| Khanh et al. (26) | Cytokeratin, TGFβ | Cox | Tumor grade, tumor depth, node status |
| Knosel et al. (29) | Cytokeratins | Cox | Not listed |
| Knosel et al. (38) | E-cadherin | Cox | Pathologic stage, venous invasion, PITX1 expression |
| Koelzer et al. (31) | E-cadherin | Cox | T-stage, M-stage, N-stage, postoperative therapy |
| Kroepil et al. (39) | E-cadherin, Snail | Cox | Age, sex, T-stage, N-stage, tumor grade |
| Meng et al. (47) | miRNA | Cox | Tumor size, CEA, histologic grade |
| Mesker et al. (24) | TGFβ, β-catenin | Cox | No adjustment covariates reported |
| Saito et al. (41) | E-cadherin, vimentin | Cox | Age, sex, location (colon vs. rectal), tumor size, histological type, lymphatic invasion, venous invasion, invasion of primary tumor, lymph node metastasis |
| Shioiri et al. (42) | E-cadherin, Slug | Cox | Age, distant metastasis, lymph node metastasis, lymphatic invasion, vessel invasion |
| Spaderna et al. (27) | E-cadherin, β-catenin, ZEB1, vimentin | Cox | Not listed |
| Yu et al. (44) | E-cadherin, Twist2 | Cox | Age, sex, T-stage, N-stage, M-stage, tumor differentiation, vascular invasion, tumor location, CEA level |
| Zlobec (28) | Cytokeratin | Cox | Tumor budding, TNM stage, tumor grade, KRAS status, BRAF status, MGMT status, microsatellite instability status, CpG island methylator status |
Abbreviations: TNM, tumor–node–metastasis; CEA, carcinoembryonic antigen.