Table 2.

Association of alcohol consumption and mortality in breast cancer cases with ER-positive tumors

UnivariateMultivariateb
StudyAlcohol intakea (U/wk)NEventsHR (95% CI)EventsHR (95% CI)
Overall mortality
SEARCH
Nondrinker1,2732181 (Ref.)1801 (Ref.)
≤72,3003900.96 (0.82–1.14)3321.02 (0.84–1.22)
>7–≤148611320.85 (0.68–1.05)1120.90 (0.71–1.14)
>14396560.77 (0.58–1.03)470.89 (0.64–1.23)
Linear (per category)4,8307960.92 (0.85–0.99)6710.95 (0.87–1.04)
EPIC
Nondrinker807871 (Ref.)501 (Ref.)
≤72,6742560.88 (0.69–1.14)1191.08 (0.76–1.53)
>7–≤141,066970.80 (0.59–1.08)430.92 (0.60–1.41)
>141,2061160.83 (0.62–1.12)510.92 (0.61–1.39)
Linear (per category)5,7535560.94 (0.86–1.03)2630.95 (0.84–1.08)
BCAC
Nondrinker2,2094231 (Ref.)2191 (Ref.)
≤72,7254020.64 (0.54–0.75)3130.56 (0.47–0.68)
>7–≤149201310.72 (0.59–0.88)790.68 (0.52–0.88)
>149821470.74 (0.61–0.91)840.64 (0.49–0.83)
Linear (per category)6,8361,1030.90 (0.84–0.95)6950.85 (0.78–0.93)
Breast cancer–specific mortality
SEARCH
Nondrinker1,2731581 (Ref.)1311 (Ref.)
≤72,3003171.08 (0.89–1.31)2741.15 (0.93–1.42)
>7–≤148611010.90 (0.70–1.15)840.94 (0.71–1.24)
>14396470.90 (0.65–1.24)381.01 (0.70–1.46)
Linear (per category)4,8306230.95 (0.87–1.04)5270.98 (0.89–1.09)
EPIC
Nondrinker807451 (Ref.)241 (Ref.)
≤72,6741210.90 (0.62–1.29)521.33 (0.78–2.27)
>7–≤141,066420.76 (0.49–1.19)171.18 (0.61–2.29)
>141,206460.76 (0.49–1.18)171.12 (0.57–2.17)
Linear (per category)5,7532540.91 (0.79–1.04)1101.01 (0.83–1.24)
BCAC
Nondrinker2,2092031 (Ref.)741 (Ref.)
≤72,7251640.65 (0.51–0.83)1160.58 (0.41–0.81)
>7–≤14920520.83 (0.61–1.14)220.97 (0.59–1.58)
>14982530.84 (0.62–1.14)210.76 (0.46–1.26)
Linear (per category)6,8364720.93 (0.84–1.02)2330.92 (0.78–1.09)
  • aSEARCH reported postdiagnosis alcohol consumption, whereas EPIC and BCAC reported prediagnosis alcohol consumption.

  • bAdjusted for stage, grade, BMI, smoking status, SES, and menopausal status (EPIC estimates were also adjusted for country).