Application of EBNA1 IgA as screening tool for incident NPC in high-risk multiplex Taiwanese family members (40+ years of age)
| Screened population | 5-year NPC risk | Sensitivity | Specificity | No. of screened/NPC casec | No. of screen-positive/NPC cased |
|---|---|---|---|---|---|
| Taiwanese multiplex family members (40+) | 762/100,000a | 80%b | 58% | 164 | 69 |
| Taiwanese multiplex family members (40+) | 762/100,000 | 90%e | 40% | 146 | 88 |
↵aEleven NPC cases were ascertained among 1,444 high-risk Taiwan multiplex family study participants at least 40 years of age at the time of the baseline blood draw (14).
↵bSensitivity and specificity generated from EBNA1 IgA COV = 0.72.
↵cNumber of screened per NPC case detected = 1/(sensitivity × 5-year NPC risk).
↵dNumber of screen-positive per NPC case detected = 1/(positive predictive value).
↵eSensitivity and specificity generated from EBNA1 IgA COV = 0.61.