Table 2.

Association between obesogenic variants and colorectal cancer risk in the DACHS population

Variant_dbSNP	Gene	Nucleotide substitution	Position^a/variant	Risk allele^b	OR (95% CI)^c	P_trend	BMI × SNPP_interaction	T2D × SNPP_interaction	Sex × SNPP_interaction
rs6265	BDNF	G/A	V66M	G	1.05 (0.93–1.17)	0.44	0.25	0.02^e	0.49
rs1919127	C2orf16	T/C	V685A	n/s	1.00 (0.90–1.11)	0.95	0.91	0.53	0.19
rs2679120	CLIP	G/C	Intron 5	G	0.97 (0.88–1.07)	0.55	0.65	0.45	0.74
rs2572106	FBXL4	A/C	5′-UTR	C	1.04 (0.94–1.15)	0.42	0.88	0.85	0.36
rs9939609	FTO	T/A	Intron 1	A	0.96 (0.87–1.05)	0.35	0.34	0.48	0.79
rs8050136	FTO	C/A	Intron 1	A	0.96 (0.88–1.06)	0.45	0.28	0.69	0.78
rs1260326	GCKR	C/T	P446L	n/s	0.91 (0.83–1.00)	0.06	0.18	0.18	0.35
rs10938397	GNPDA2	A/G	5′-UTR	G	1.10 (1.00–1.21)	0.04	0.85	0.16	0.34
rs4623795	ITIH5	G/C	Intron 3	G	0.98 (0.86–1.12)	0.78	0.30	0.93	0.51
rs11084753	KCTD15	G/A	3′-UTR	G	1.05 (0.95–1.16)	0.35	0.79	0.23	0.71
rs1041981	LTA	C/A	T60N	A	1.00 (0.91–1.11)	0.99	0.34	0.91	0.002^f
rs1424233	MAF	G/A	5′-UTR	A	1.00 (0.91–1.10)	0.92	0.27	0.54	0.81
rs17782313	MC4R	T/C	3′-UTR	C	0.93 (0.84–1.04)	0.19	0.22	0.45	0.39
rs17700633	MC4R	G/A	3′-UTR	A	0.91 (0.83–1.01)	0.08	0.73	0.71	0.98
rs12970134	MC4R	G/A	3′-UTR	A	0.94 (0.84–1.04)	0.22	0.41	0.76	0.25
rs10838738	MTCH2	A/G	Intron 1	G	1.00 (0.91–1.11)	0.93	0.51	0.17	0.51
rs7336049	MYO16	C/G	5′-UTR	G	0.99 (0.90–1.10)	0.91	0.04^d	0.67	0.46
rs2568958	NEGR1	A/G	5′-UTR	A	0.97 (0.88–1.07)	0.54	0.55	0.62	0.04ⁱ
rs1805081	NPC1	A/G	H215R	n/s	0.98 (0.89–1.07)	0.62	0.08	0.05	0.03^g
rs6235	PCSK1	G/C	S690T	n/s	0.97 (0.87–1.08)	0.55	0.57	0.13	0.03^k
rs6232	PCSK1	A/G	N221D	n/s	1.05 (0.85–1.30)	0.65	0.40	0.84	0.13
rs7212681	RABEP1	T/G	Intron 1	G	1.00 (0.91–1.10)	0.97	0.98	0.68	0.07
rs7498665	SH2B1	A/G	T484A	G	0.93 (0.85–1.02)	0.13	0.37	0.98	0.03^j
rs10769908	STK33	T/C	Intron 5	C	1.01 (0.92–1.11)	0.88	0.44	0.77	0.17
rs35859249	TBC1D1	C/T	R125W	T	0.99 (0.84–1.17)	0.93	0.89	0.25	0.91
rs6548238	TMEM18	C/T	3′-UTR	C	1.00 (0.89–1.13)	0.99	0.32	0.95	0.04^h

Abbreviations: n/s, not specified; UTR, untranslated region.

↵^aPosition denotes the location of an SNP in relation to the gene, i.e., 5′-UTR, 3′-UTR, or within the gene.
↵^bBMI-increasing allele according to recent GWAS on obesity risk.
↵^cEstimates were adjusted for age, sex, and county of residence. P < 0.05 in bold.
↵^dMYO16_rs7336049 (OR_{BMI<25 kg/m²}, 0.94; 95% CI, 0.78–1.14; OR_{BMI≥25<30kg/m²}, 1.12; 95% CI, 0.95–1.31; and OR_{BMI≥30 kg/m²}, = 0.75; 95% CI, 0.58–0.99).
↵^eBDNF_rs6265 (OR_Diabetic, 1.50; 95% CI, 1.06–2.13 vs. OR_Nondiabetic, 0.98; 95% CI, 0.86–1.12).
↵^fLTA_rs1041981 (OR_Female, 0.83; 95% CI, 0.71–0.97 vs. OR_Male, 1.14, 95% CI, 1.00–1.30).
↵^gNPC1_rs1805081 (OR_Female, 0.86; 95% CI, 0.74–1.00 vs. OR_Male, 1.06; 95% CI, 0.94–1.20).
↵^hTMEM18_rs6548238 (OR_Female, 1.17; 95% CI, 0.96–1.42 vs. OR_Male, 0.90; 95% CI, 0.77–1.06).
↵ⁱNEGR1_rs2568958 (OR_Female, 0.86; 95% CI, 0.75–1.00 vs. OR_Male, 1.06; 95% CI, 0.94–1.20).
↵^jSH2B1_rs7498665 (OR_Female, 0.82; 95% CI, 0.71–0.95 vs. OR_Male, 1.01; 95% CI, 0.90–1.15).
↵^kPCSK1_rs6235 (OR_Female, 1.11; 95% CI, 0.95–1.31 vs. OR_Male, 0.88; 95% CI, 0.76–1.01).