Table 2.

Association between obesogenic variants and colorectal cancer risk in the DACHS population

Variant_dbSNPGeneNucleotide substitutionPositiona/variantRisk allelebOR (95% CI)cPtrendBMI × SNPPinteractionT2D × SNPPinteractionSex × SNPPinteraction
rs6265BDNFG/AV66MG1.05 (0.93–1.17)0.440.250.02e0.49
rs1919127C2orf16T/CV685An/s1.00 (0.90–1.11)0.950.910.530.19
rs2679120CLIPG/CIntron 5G0.97 (0.88–1.07)0.550.650.450.74
rs2572106FBXL4A/C5′-UTRC1.04 (0.94–1.15)0.420.880.850.36
rs9939609FTOT/AIntron 1A0.96 (0.87–1.05)0.350.340.480.79
rs8050136FTOC/AIntron 1A0.96 (0.88–1.06)0.450.280.690.78
rs1260326GCKRC/TP446Ln/s0.91 (0.83–1.00)0.060.180.180.35
rs10938397GNPDA2A/G5′-UTRG1.10 (1.00–1.21)0.040.850.160.34
rs4623795ITIH5G/CIntron 3G0.98 (0.86–1.12)0.780.300.930.51
rs11084753KCTD15G/A3′-UTRG1.05 (0.95–1.16)0.350.790.230.71
rs1041981LTAC/AT60NA1.00 (0.91–1.11)0.990.340.910.002f
rs1424233MAFG/A5′-UTRA1.00 (0.91–1.10)0.920.270.540.81
rs17782313MC4RT/C3′-UTRC0.93 (0.84–1.04)0.190.220.450.39
rs17700633MC4RG/A3′-UTRA0.91 (0.83–1.01)0.080.730.710.98
rs12970134MC4RG/A3′-UTRA0.94 (0.84–1.04)0.220.410.760.25
rs10838738MTCH2A/GIntron 1G1.00 (0.91–1.11)0.930.510.170.51
rs7336049MYO16C/G5′-UTRG0.99 (0.90–1.10)0.910.04d0.670.46
rs2568958NEGR1A/G5′-UTRA0.97 (0.88–1.07)0.540.550.620.04i
rs1805081NPC1A/GH215Rn/s0.98 (0.89–1.07)0.620.080.050.03g
rs6235PCSK1G/CS690Tn/s0.97 (0.87–1.08)0.550.570.130.03k
rs6232PCSK1A/GN221Dn/s1.05 (0.85–1.30)0.650.400.840.13
rs7212681RABEP1T/GIntron 1G1.00 (0.91–1.10)0.970.980.680.07
rs7498665SH2B1A/GT484AG0.93 (0.85–1.02)0.130.370.980.03j
rs10769908STK33T/CIntron 5C1.01 (0.92–1.11)0.880.440.770.17
rs35859249TBC1D1C/TR125WT0.99 (0.84–1.17)0.930.890.250.91
rs6548238TMEM18C/T3′-UTRC1.00 (0.89–1.13)0.990.320.950.04h

Abbreviations: n/s, not specified; UTR, untranslated region.

  • aPosition denotes the location of an SNP in relation to the gene, i.e., 5′-UTR, 3′-UTR, or within the gene.

  • bBMI-increasing allele according to recent GWAS on obesity risk.

  • cEstimates were adjusted for age, sex, and county of residence. P < 0.05 in bold.

  • dMYO16rs7336049 (ORBMI<25 kg/m2, 0.94; 95% CI, 0.78–1.14; ORBMI≥25<30kg/m2, 1.12; 95% CI, 0.95–1.31; and ORBMI≥30 kg/m2, = 0.75; 95% CI, 0.58–0.99).

  • eBDNFrs6265 (ORDiabetic, 1.50; 95% CI, 1.06–2.13 vs. ORNondiabetic, 0.98; 95% CI, 0.86–1.12).

  • fLTArs1041981 (ORFemale, 0.83; 95% CI, 0.71–0.97 vs. ORMale, 1.14, 95% CI, 1.00–1.30).

  • gNPC1rs1805081 (ORFemale, 0.86; 95% CI, 0.74–1.00 vs. ORMale, 1.06; 95% CI, 0.94–1.20).

  • hTMEM18rs6548238 (ORFemale, 1.17; 95% CI, 0.96–1.42 vs. ORMale, 0.90; 95% CI, 0.77–1.06).

  • iNEGR1rs2568958 (ORFemale, 0.86; 95% CI, 0.75–1.00 vs. ORMale, 1.06; 95% CI, 0.94–1.20).

  • jSH2B1rs7498665 (ORFemale, 0.82; 95% CI, 0.71–0.95 vs. ORMale, 1.01; 95% CI, 0.90–1.15).

  • kPCSK1rs6235 (ORFemale, 1.11; 95% CI, 0.95–1.31 vs. ORMale, 0.88; 95% CI, 0.76–1.01).