Table 3.

Multivariablea HRs and 95% CIs for risk of thyroid cancer across categories of tea consumption and intakes of oranges and tangelo, orange and grapefruit juice, legumes, grapes, and bananas in the NIH–AARP Diet and Health Study (1995–1996)

Categories of intake
Tea, frequency of consumption
0≤1 cup/wk>1 cup/wk–1 cup/d>1–3 cup/d>3 cup/dPTrend
Cases62/436,791122/879,965171/1,448,058139/1,122,15292/589,096
 HR (95% CI)Ref0.95 (0.70, 1.29)0.79 (0.59, 1.06)0.80 (0.59, 1.09)0.97 (0.70, 1.35)0.81
Top dietary contributors of flavonoids, quintile
12345
Oranges and tangelos
 Cases106/884,298116/897,352118/898,369130/899,732116/896,313
 Median intake (range)b0.00 (0.00–0.04)0.03 (0.00–0.12)0.07 (0.01–0.32)0.20 (0.03–0.99)0.48 (0.07–3.52)
 HR (95% CI)Ref1.06 (0.81, 1.39)1.04 (0.80, 1.37)1.14 (0.88, 1.48)1.00 (0.77, 1.31)0.79
Orange and grapefruit juice
 Cases86/888,222125/899,581110/898,523125/896,001140/893,737
 Median intake (range)b0.01 (0.00–0.02)0.04 (0.02–0.09)0.16 (0.07–0.27)0.38 (0.26–0.53)0.76 (0.51–7.26)
 HR (95% CI)Ref1.42 (1.08, 1.87)1.29 (0.97, 1.71)1.46 (1.11, 1.93)1.55 (1.18, 2.03)0.004
Legumes
 Casesc171/1,133,64885/768,574135/937,38999/780,39996/856,054
 Median intake (range)b0.01 (0.00–0.03)0.03 (0.02–0.05)0.06 (0.04–0.08)0.10 (0.07–0.16)0.23 (0.13–5.34)
 HR (95% CI)Ref0.75 (0.58, 0.97)1.01 (0.81, 1.27)0.94 (0.73, 1.21)0.86 (0.66, 1.12)0.62
Grape
 Casesc163/1,303,239125/836,769114/784,333102/793,92282/757,802
 Median intake (range)b0.00 (0.00–0.01)0.02 (0.01–0.02)0.05 (0.02–0.05)0.05 (0.05–0.13)0.32 (0.13–3.90)
 HR (95% CI)Ref1.19 (0.95, 1.51)1.13 (0.89, 1.44)1.05 (0.82, 1.35)0.90 (0.69, 1.18)0.49
Banana
 Casesc183/1,395,806110/895,308137/961,28173/562,43783/661,197
 Median intake (range)b0.03 (0.00–0.05)0.15 (0.07–0.15)0.35 (0.18–0.35)0.54 (0.42–0.54)0.74 (0.68–1.94)
 HR (95% CI)Ref0.93 (0.73, 1.18)1.07 (0.86, 1.34)0.98 (0.75, 1.29)0.96 (0.74, 1.25)0.97
  • aAdjusted for sex (male and female), total caloric intake (continuous), smoking status (current, former, and never), education level (less than 12 years, high school graduate, some college, college graduate, and missing), alcohol intake (0–<0.05, 0.05–<0.5, 0.5–<1, 1+ drinks per day), race (white, black, other, and missing), body mass index (<25, 25–<30, 30–<35, 35+ kg/m2), and family history of cancer (no, yes, and missing).

  • bServing/d/1,000 cal.

  • cThe quintiles were not equally distributed because of the clusters of participants with the same values of intake.