Table 3.

Cross-correlations between changes in biomarkersa

COTΔ1COTΔ2NICΔ1NICΔ2NNALΔ1NNALΔ22HPMAΔ13HPMAΔ1AAMAΔ1CNEMAΔ1MHBMAΔ1HEMAΔ1PMAΔ1
COTΔ110.90b0.190.44b0.73b0.75b−0.040.29c0.74b0.84b0.100.65b0.92b
COTΔ210.090.51b0.71b0.78b−0.080.230.73b0.86b0.090.67b0.92b
NICΔ110.52b0.090.12−0.170.180.060.080.060.230.01
NICΔ210.59b0.66b−0.010.42d0.53b0.43b0.090.31c0.35d
NNALΔ110.94b0.34d0.36d0.76b0.70b0.080.33c0.64b
NNALΔ210.090.42d0.86b0.79b0.100.44b0.69b
2HPMAΔ11−0.10−0.03−0.13−0.07−0.34c−0.10
3HPMAΔ110.27c0.240.160.240.35d
AAMAΔ110.85b0.090.45b0.68b
CNEMAΔ110.120.64b0.82b
MHBMAΔ110.30c0.14
HEMAΔ110.70b
PMAΔ11
  • aAll subjects included in the analysis; COT, cotinine; NIC, nicotine; NNAL, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; VOC mercapturic acid metabolites (parent compound in parenthesis): 2HPMA, 2-hydroxypropyl (propylene oxide); 3-HPMA, 3-hydroxypropyl (acrolein); AAMA, 2-carbamoylethyl (acrylamide); CNEMA, cyanoethyl (acrylonitrile); MHBMA, 2-hydroxy-3-buten-1-yl or isomer(s) (1,3-butadiene); HEMA, 2-hydroxyethyl (ethylene oxide); PMA, phenyl (benzene); Δ1, post-minus preexposure; Δ2, next day minus preexposure; VOC mercapturic acid metabolites were only measured in preexposure and postexposure samples.

  • bP < 0.001.

  • cP < 0.05.

  • dP < 0.01.