Table 1.

Overview of FeNO and of breath biomarkers measured in EBC in asbestos-related diseases

MarkerDisease (n)Control subjects (n)MethodResultRef.
Oxidative stress
 H2O2Asbestosis (18)
Pleural plaques (26)Healthy (26)EcoScreen + EIAAsbestosis > HC(34)
DPT (16)
 8-isoprostaneAsbestos-exposed (92)Healthy (46)SPE + LC-ESI-MS/MSAsbestos-exposed > HC(38)
Asbestos-exposed (44)NASPE + LC-ESI-MS/MSAsbestos-exposed > HC(40)
Asbestos-exposed (45)Healthy (29)SPE + LC-ESI-MS/MSAsbestos-exposed > HC(39)
Asbestosis (15)Healthy (15)EcoScreen + EIAAsbestosis > HC(36)
Asbestosis (18)
Pleural plaques (26)Healthy (26)EcoScreen + EIAAsbestosis > HC(34)
DPT (16)
Asbestos-exposed (66)Healthy, nonexposed (41)Chemoluminiscence NO analyzerAsbestos-exposed > HC(41)
 HNEAsbestos-exposed (45)Healthy (29)SPE + LC-ESI-MS/MSAsbestos-exposed > HC(39)
 8-OHdGAsbestosis (10)Healthy (10)Lyophilization + LC-ESI-MS/MSAsbestosis > HC(35)
 FeNOAsbestosis (12)Chemoluminiscence NO analyzerAsbestosis > HC(45)
Pleural plaques (32)Healthy (35)Pleural plaques > HC
DPT (12)
Asbestosis (15)Healthy (15)Chemoluminiscence NO analyzerNo differences(36)
Asbestos-exposed (66)Healthy, nonexposed (41)Chemoluminiscence NO analyzerAsbestos-exposed > HC(41)
Lipid peroxidation
 LTB4Asbestosis (45)Healthy (27)SPE + LC-ESI-MS/MSAsbestosis > HC(37)
Silicosis (37)Asbestosis > Silicosis
Asbestosis (15)Healthy (15)EcoScreen condensor + EIAAsbestosis > HC(36)
Asbestos-exposed (66)Healthy, nonexposed (41)EcoScreen condensor + EIAAsbestos-exposed > HC(41)
 LTC4, D4, E4LTD4+LTE4:
Asbestosis (45)Healthy (27)SPE + LC-ESI-MS/MSAsbestosis > HC(37)
Silicosis (37)Silicosis > HC
LTC4: no differences

Abbreviations: 8-isoprostane, 8-iso-prostaglandine F; EIA, enzyme immunoassay; HC, healthy control; NA, not applicable.