Table 1.

Distribution of selected epidemiological variables in the DACHS study population

CasesControls
(N = 1,792)(N = 1,805)
ValueN (%)N (%)P
Age (y)
 30 to <4017 (0.95)5 (0.28)0.02
 40 to <5058 (3.24)60 (3.32)
 50 to <60269 (15.01)260 (14.40)
 60 to <70622 (34.71)574 (31.80)
 70 to <80568 (31.70)615 (34.00)
 80+258 (14.40)295 (16.30)
Gender
 Female743 (41.46)732 (40.55)0.60
 Male1,049 (58.54)1,073 (59.45)
BMI (kg/m2) ≥5 years before diagnosis/date of interview
 ≥18.5 to <25551 (30.75)667 (36.95)<0.01
 ≥25 to <30835 (46.60)845 (46.81)
 ≥30361 (20.15)268 (14.85)
 Unknown45 (2.51)25 (1.39)
Average alcohol intake in last 12 months (g/day)a
 None529 (29.52)466 (25.82)<0.01
 0< to <6.1 g/day261 (14.56)300 (16.62)
 ≥ 6.1 to <13.2 g/day287 (16.02)335 (18.56)
 ≥ 13.2 to <25.5 g/day302 (16.85)334 (18.50)
 ≥ 25.5 g/day392 (21.88)325 (18.01)
 Unknown21 (1.17)45 (2.49)
Average lifetime pack years of regular smoking
 Nonsmoker837 (46.71)935 (51.80)<0.01
 >0 to <10298 (16.63)314 (17.40)
 10 to <20219 (12.22)201 (11.14)
 20 to <30187 (10.44)160 (8.86)
 ≥30232 (12.95)180 (9.97)
 Unknown19 (1.06)15 (0.83)
First degree family history of colorectal cancer
 No1,529 (85.32)1,600 (88.64)0.01
 Yes259 (14.45)202 (11.19)
 Unknown4 (0.22)3 (0.17)
Ever been diagnosed with diabetes (through a physician)a
 No1,452 (81.03)1,553 (86.04)<0.01
 Yes324 (18.08)247 (13.68)
 Unknown16 (0.9)5 (0.28)
Ever colorectal endoscopyb
 No/unknown1,419 (79.19)847 (46.93)<0.01
 Yes372 (20.76)958 (53.07)
 Unknown1 (0.06)0 (0.00)
Ever use of hormone replacement therapyc
 No500 (67.29)357 (48.77)<0.01
 Yes238 (32.03)373 (50.96)
 Unknown5 (0.67)2 (0.27)
Ever regular use of NSAIDs 2+ times/week ≥ 1 yeara
 No1,381 (77.06)1,249 (69.20)<0.01
 Yes403 (22.49)549 (30.42)
 Unknown8 (0.44)7 (0.39)
Colorectal cancer localization
 Colon1,094 (61.05)n/an/a
 Rectum698 (38.95)n/a

Abbreviation: n/a, characteristic only available for cases.

  • aBefore reference date, which equals date of diagnosis among cases and date of recruitment among controls.

  • bFor cases excluding endoscopies conducted as part of the diagnostic process.

  • cIn women only.