Distribution of selected epidemiological variables in the DACHS study population
| Cases | Controls | ||
|---|---|---|---|
| (N = 1,792) | (N = 1,805) | ||
| Value | N (%) | N (%) | P |
| Age (y) | |||
| 30 to <40 | 17 (0.95) | 5 (0.28) | 0.02 |
| 40 to <50 | 58 (3.24) | 60 (3.32) | |
| 50 to <60 | 269 (15.01) | 260 (14.40) | |
| 60 to <70 | 622 (34.71) | 574 (31.80) | |
| 70 to <80 | 568 (31.70) | 615 (34.00) | |
| 80+ | 258 (14.40) | 295 (16.30) | |
| Gender | |||
| Female | 743 (41.46) | 732 (40.55) | 0.60 |
| Male | 1,049 (58.54) | 1,073 (59.45) | |
| BMI (kg/m2) ≥5 years before diagnosis/date of interview | |||
| ≥18.5 to <25 | 551 (30.75) | 667 (36.95) | <0.01 |
| ≥25 to <30 | 835 (46.60) | 845 (46.81) | |
| ≥30 | 361 (20.15) | 268 (14.85) | |
| Unknown | 45 (2.51) | 25 (1.39) | |
| Average alcohol intake in last 12 months (g/day)a | |||
| None | 529 (29.52) | 466 (25.82) | <0.01 |
| 0< to <6.1 g/day | 261 (14.56) | 300 (16.62) | |
| ≥ 6.1 to <13.2 g/day | 287 (16.02) | 335 (18.56) | |
| ≥ 13.2 to <25.5 g/day | 302 (16.85) | 334 (18.50) | |
| ≥ 25.5 g/day | 392 (21.88) | 325 (18.01) | |
| Unknown | 21 (1.17) | 45 (2.49) | |
| Average lifetime pack years of regular smoking | |||
| Nonsmoker | 837 (46.71) | 935 (51.80) | <0.01 |
| >0 to <10 | 298 (16.63) | 314 (17.40) | |
| 10 to <20 | 219 (12.22) | 201 (11.14) | |
| 20 to <30 | 187 (10.44) | 160 (8.86) | |
| ≥30 | 232 (12.95) | 180 (9.97) | |
| Unknown | 19 (1.06) | 15 (0.83) | |
| First degree family history of colorectal cancer | |||
| No | 1,529 (85.32) | 1,600 (88.64) | 0.01 |
| Yes | 259 (14.45) | 202 (11.19) | |
| Unknown | 4 (0.22) | 3 (0.17) | |
| Ever been diagnosed with diabetes (through a physician)a | |||
| No | 1,452 (81.03) | 1,553 (86.04) | <0.01 |
| Yes | 324 (18.08) | 247 (13.68) | |
| Unknown | 16 (0.9) | 5 (0.28) | |
| Ever colorectal endoscopyb | |||
| No/unknown | 1,419 (79.19) | 847 (46.93) | <0.01 |
| Yes | 372 (20.76) | 958 (53.07) | |
| Unknown | 1 (0.06) | 0 (0.00) | |
| Ever use of hormone replacement therapyc | |||
| No | 500 (67.29) | 357 (48.77) | <0.01 |
| Yes | 238 (32.03) | 373 (50.96) | |
| Unknown | 5 (0.67) | 2 (0.27) | |
| Ever regular use of NSAIDs 2+ times/week ≥ 1 yeara | |||
| No | 1,381 (77.06) | 1,249 (69.20) | <0.01 |
| Yes | 403 (22.49) | 549 (30.42) | |
| Unknown | 8 (0.44) | 7 (0.39) | |
| Colorectal cancer localization | |||
| Colon | 1,094 (61.05) | n/a | n/a |
| Rectum | 698 (38.95) | n/a | |