Table 4.

Multivariate analyses for lung cancer risk–related SNPs on MN frequency of coke oven workers

Aa vs. AAaa vs. AAAa+aa vs. AA
SNP [major (A)/minor allele (a)]β (95% CI)aPaβ (95% CI)aPaβ (95% CI)aPaPbFDR
rs10937405 (C/T)−0.009 (−0.063 to 0.046)0.756−0.102 (−0.205 to 0.001)0.050−0.022 (−0.075 to 0.030)0.4030.1440.360
rs11080466 (A/G)0.037 (−0.019 to 0.094)0.190−0.020 (−0.151 to 0.111)0.7640.029 (−0.025 to 0.083)0.2930.3730.547
rs1333040 (T/C)−0.090 (−0.146 to −0.035)0.0010.014 (−0.076 to 0.103)0.765−0.066 (−0.118 to −0.014)0.0130.0020.025
rs1663689 (A/G)−0.036 (−0.094 to 0.021)0.213−0.145 (−0.224 to −0.065)<0.001−0.067 (−0.121 to −0.013)0.0160.0010.025
rs2131877 (T/C)0.044 (−0.017 to 0.105)0.1590.080 (0.005–0.156)0.0360.060 (0.003–0.118)0.0400.1030.291
rs247008 (C/T)0.063 (−0.001 to 0.127)0.0520.016 (−0.059 to 0.091)0.6740.045 (−0.015 to 0.106)0.1450.1050.291
rs2895680 (T/C)−0.048 (−0.104 to 0.007)0.0890.007 (−0.083 to 0.097)0.884−0.033 (−0.085 to 0.020)0.2210.1910.398
rs36600 (C/T)0.040 (−0.029 to 0.109)0.2560.102 (−0.145 to 0.350)0.4160.045 (−0.022 to 0.112)0.1910.3940.547
rs3813572 (A/G)−0.083 (−0.142 to −0.025)0.005−0.146 (−0.299 to 0.007)0.062−0.094 (−0.151 to −0.038)0.0010.0050.042
rs4488809 (C/T)0.024 (−0.039 to 0.087)0.456−0.064 (−0.139 to 0.010)0.091−0.002 (−0.062 to 0.057)0.9370.0290.181
rs4677662 (T/C)0.041 (−0.014 to 0.096)0.1400.074 (−0.022 to 0.170)0.1310.047 (−0.005 to 0.099)0.0770.1700.386
rs4809957 (G/A)−0.064 (−0.122 to −0.007)0.029−0.053 (−0.129 to 0.024)0.177−0.070 (−0.124 to −0.016)0.0110.0810.289
rs753955 (T/C)0.020 (−0.035 to 0.075)0.475−0.106 (−0.203 to −0.009)0.032−0.002 (−0.055 to 0.050)0.9320.0420.210
rs16988393 (T/C)−0.007 (−0.075 to 0.061)0.838−0.387 (−0.710 to −0.063)0.019−0.019 (−0.086 to 0.048)0.5800.0640.267
  • aβ (95% CI) and P values were derived from the comparisons with the reference genotype (AA) using a poisson log-linear model for MN frequency, adjusting for covariants (gender, years worked, smoking status, alcohol use, BMI, ΣOH–PAHs, and BPDE-albumin adducts).

  • bA P value is for the genotype term in the model, adjusting for all covariants mentioned above.