Table 3.

Multivariate analyses for lung cancer risk–related SNPs on urinary 8-OHdG levels of coke oven workers

Aa vs. AAaa vs. AAAa+aa vs. AA
SNPs [major (A)/minor allele (a)]β (95% CI)aPaβ (95% CI)aPaβ (95% CI)aPaPbFDR
rs10937405 (C/T)−0.102 (−0.206 to 0.002)0.053−0.105 (−0.288 to 0.079)0.264−0.068 (−0.179 to 0.043)0.2310.1250.511
rs11080466 (A/G)−0.046 (−0.153 to 0.061)0.397−0.234 (−0.471 to 0.003)0.053−0.048 (−0.163 to 0.067)0.4150.1320.511
rs1333040 (T/C)0.039 (−0.065 to 0.143)0.4610.152 (−0.019 to 0.322)0.0810.023 (−0.088 to 0.134)0.6850.2110.511
rs2131877 (T/C)−0.032 (−0.147 to 0.082)0.581−0.124 (−0.267 to 0.020)0.091−0.045 (−0.167 to 0.077)0.4660.2250.511
rs247008 (C/T)−0.135 (−0.254 to −0.016)0.026−0.112 (−0.251 to 0.028)0.117−0.146 (−0.274 to −0.019)0.0250.0780.511
rs2736100 (T/G)−0.134 (−0.244 to −0.025)0.016−0.080 (−0.231 to 0.072)0.303−0.100 (−0.217 to 0.018)0.0960.0560.511
rs2853677 (T/C)−0.091 (−0.198 to 0.016)0.0970.003 (−0.154 to 0.160)0.967−0.057 (−0.172 to 0.058)0.3310.1910.511
rs36600 (C/T)−0.126 (−0.256 to 0.003)0.0560.088 (−0.401 to 0.577)0.725−0.117 (−0.261 to 0.027)0.1100.1460.511
rs3813572 (A/G)−0.075 (−0.184 to 0.034)0.180−0.047 (−0.335 to 0.240)0.746−0.141 (−0.259 to −0.022)0.0200.4010.689
rs465498 (T/C)0.001 (−0.111 to 0.113)0.981−0.093 (−0.374 to 0.188)0.515−0.081 (−0.201 to 0.040)0.1880.8050.875
rs4677662 (T/C)−0.005 (−0.109 to 0.099)0.923−0.132 (−0.314 to 0.051)0.158−0.039 (−0.151 to 0.072)0.4870.3550.689
rs6495309 (C/T)0.060 (−0.053 to 0.173)0.3000.126 (−0.018 to 0.270)0.0850.085 (−0.035 to 0.206)0.1640.2210.511
rs667282 (T/C)0.069 (−0.044 to 0.182)0.2310.131 (−0.009 to 0.272)0.0660.109 (−0.010 to 0.229)0.0730.1740.511
rs753955 (T/C)0.029 (−0.076 to 0.133)0.5910.297 (0.124–0.471)0.0010.074 (−0.037 to 0.186)0.1920.0030.075
  • aβ (95% CI) and P values were derived from the comparisons with the reference genotype (AA) using a general linear model for ln-transformed 8-OHdG, adjusting for covariants (gender, years worked, smoking status, alcohol use, BMI, ΣOH–PAHs, and BPDE-albumin adducts).

  • bA P value is for the genotype term in the model, adjusting for all covariants mentioned above.