Table 3.

Demographic and clinical characteristic associations with breast cancer intrinsic subtype from PAM50 assay, LACE and Pathways cohort: ORs for non-luminal A subtypes versus luminal A

Intrinsic subtypea from PAM50
TotalLumALumBLumB vs. LumAHER2EHER2E vs. LumABasalBasal vs. LumA
n%b%bORc95% CI%bORc95% CI%bORc95% CI
Age at diagnosis
 <40912.98.12.480.98–6.295.51.720.68–4.3410.83.051.40–6.65
 40–4926614.220.71.270.72–2.2716.31.030.59–1.7926.51.510.93–2.46
 50–5941528.332.41Reference31.61Reference35.01Reference
 60–6933431.920.80.570.33–0.9728.80.810.49–1.3217.50.440.27–0.72
 70–7918419.115.50.710.39–1.3015.20.710.39–1.299.50.410.22–0.76
 80+293.62.40.570.17–1.952.60.650.19–2.300.60.130.028–0.61
PTrend0.0010.05<0.0001
Race/ethnicity
 White91375.574.31Reference70.11Reference60.91Reference
 Black or African American1155.62.90.510.19–1.336.11.150.55–2.3821.34.382.29–8.39
 Hispanic1237.310.41.290.63–2.6210.61.460.71–3.0110.51.470.82–2.63
 Asian or Pacific Islander1319.59.60.890.46–1.739.00.930.55–1.544.70.480.25–0.92
 American Indian or Alaska Native221.02.52.90.45–10.32.92.740.61–12.42.01.950.52–7.33
 Other371.00.30.300.05–1.761.31.470.37–5.870.60.770.13–4.80
Grade
 Well-differentiated16233.29.91Reference8.81Reference1.21Reference
 Moderately differentiated45346.947.73.191.65–6.1539.23.061.40–6.6911.76.312.11–18.8
 Poor/undifferentiated6309.438.612.806.14–26.547.418.508.30–41.382.5217.4074.6–633.8
 Unknown7210.53.81.230.41–3.724.61.680.53–5.304.713.203.44–50.9
P trend<0.0001<0.0001<0.0001
Stage
 I56257.236.11Reference38.51Reference44.01Reference
 II60737.852.02.041.34–3.1255.02.091.40–3.1149.61.471.01–2.12
 III905.010.83.051.45–6.405.71.600.81–3.175.21.050.51–2.15
 IV120.11.124.502.23–269.60.920.702.24–192.21.214.901.59–139.1
PTrend<0.0001<0.00010.06
Tumor size
 ≤2 cm79774.954.31Reference55.81Reference56.01Reference
 >2 cm52225.145.72.361.56–3.5644.22.291.53–3.4144.02.061.43–2.96
Positive lymph nodes
 083270.259.01Reference58.01Reference72.91Reference
 1–332122.825.31.180.73–1.9029.91.500.97–2.3219.80.680.43–1.07
 4+1396.915.62.481.30–4.7112.22.051.11–3.767.40.870.48–1.60
PTrend0.010.0070.19
  • aLumA, luminal A; LumB, luminal B; HER2E, HER2-enriched; Basal, basal-like. The normal-like subtype accounted for fewer than 5% of subtype results and is not shown.

  • bEstimated distribution of characteristics within the subtype category after correction for sampling weights.

  • cPrevalence ORs for cross-sectional association between subject or clinical characteristic at diagnosis and non-luminal A subtype.