Table 2.

Associations between selected SNPs and multiple myeloma risk in the IMMEnSE consortium

IMMEnSEOriginal study
GeneSNPCases N (%)Controls N (%)OR (95% CI)PPtrendBest OR (95% CI)PInheritance model
SERPINE1rs22276670.39c (0.24–0.64)0.0002Dominant
A/A762 (59.2)1,080 (59.6)1 (—)0.930
A/G457 (35.5)623 (34.4)1.00 (0.85–1.17)0.981
G/G68 (5.3)109 (6.0)0.83 (0.60–1.15)0.257
A/A vs. A/G+G/G0.97 (0.84–1.13)0.717
A/A+A/G vs. G/G0.91 (0.77–1.07)0.251
A vs. G0.95 (0.84–1.08)0.460
CCR7rs31366850.38c (0.22–0.64)0.0004Dominant
G/G907 (70.2)1,275 (70.2)1 (—)0.650
A/G342 (26.5)486 (26.8)1.03 (0.87–1.22)0.719
A/A43 (3.3)54 (3.0)1.17 (0.77–1.80)0.458
G/G vs. A/G+A/A1.04 (0.89–1.23)0.588
G/G+A/G vs. A/A1.08 (0.87–1.33)0.479
G vs. A1.05 (0.91–1.21)0.486
HGFrs175011082.75c (1.69–4.48)4.6 × 10−5Dominant
G/G984 (77.2)1,366 (76.6)1 (—)0.017
G/T274 (21.5)386 (21.7)1.03 (0.86–1.24)0.718
T/T16 (1.3)30 (1.7)0.74 (0.40–1.39)0.352
G/G vs. G/T+T/T1.01 (0.85–1.21)0.894
G/G+G/T vs. T/T0.86 (0.63–1.17)0.340
G vs. T0.99 (0.84–1.16)0.865
BAXrs10422650.40c (0.21–0.78)0.007Dominant
C/C1,076 (83.4)1,469 (81.5)1 (—)0.799
C/T194 (15.0)317 (17.6)0.85 (0.70–1.04)0.120
T/T20 (1.6)16 (0.9)1.89 (0.96–3.74)0.065
C/C vs. C/T+T/T0.90 (0.74–1.09)0.293
C/C+C/T vs. T/T1.39 (0.99–1.96)0.055
C vs. T0.96 (0.80–1.45)0.648
CASP9rs75164352.59c (1.30–5.15)0.007Recessive
A/A623 (49.2)895 (49.7)1 (—)0.725
A/G534 (42.1)724 (40.3)1.05 (0.90–1.23)0.514
G/G110 (8.7)179 (10.0)0.91 (0.70–1.19)0.511
A/A vs. A/G+G/G1.03 (0.88–1.19)0.730
A/A+A/G vs. G/G0.94 (0.83–1.07)0.388
A vs. G0.99 (0.89–1.11)0.905
MTHFRrs18011331.27 (1.02–1.58)Dominant (meta)
G/G554 (43.8)767 (42.7)1 (—)0.721
A/G525 (41.5)787 (43.8)0.91 (0.78–1.07)0.267
A/A185 (14.7)243 (13.5)0.96 (0.77–1.21)0.757
G/G vs. A/G+A/A0.92 (0.80–1.07)0.312
G/G+A/G vs. A/A1.00 (0.90–1.12)0.929
G vs. A0.96 (0.86–1.07)0.500
mEHrs22349225.81 (1.27–35.7)0.01Recessive
A/A860 (67.0)1,150 (63.4)1 (—)0.635
A/G369 (28.7)596 (32.8)0.86 (0.74–1.02)0.081
G/G55 (4.3)70 (3.8)1.14 (0.78–1.66)0.502
A/A vs. A/G+G/G0.89 (0.76–1.04)0.155
A/A+A/G vs. G/G1.09 (0.91–1.31)0.356
A vs. G0.94 (0.83–1.07)0.378
MTRrs18050872.31 (1.38–3.87)0.001Dominant
A/A858 (67.3)1,201 (66.2)1 (—)0.974
A/G372 (29.2)549 (30.3)0.97 (0.83–1.14)0.734
G/G45 (3.5)63 (3.5)1.18 (0.78–1.77)0.430
A/A vs. A/G+G/G0.99 (0.85–1.16)0.916
A/A+A/G vs. G/G1.09 (0.89–1.33)0.402
A vs. G1.01 (0.88–1.16)0.852
IL1βrs16944a0.057 (0.02–0.18)0.0001Log-additive
G/G471 (44.1)686 (43.6)1 (—)0.522
A/G461 (43.2)718 (45.7)0.90 (0.76–1.07)0.240
A/A136 (12.7)169 (10.7)1.11 (0.86–1.45)0.427
G/G vs. A/G+A/A0.94 (0.80–1.11)0.476
G/G+A/G vs. A/A1.08 (0.96–1.22)0.212
G vs. A1.00 (0.89–1.13)0.944
TNF-αrs1800629b0.58 (0.39–0.87)0.01Log-additive
G/G478 (75.9)859 (72.7)1 (—)0.187
A/G143 (22.7)289 (24.5)0.88 (0.70–1.12)0.317
A/A9 (1.4)33 (2.8)0.48 (0.22–1.05)0.066
G/G vs. A/G+A/A0.84 (0.67–1.06)0.152
G/G+A/G vs. A/A0.71 (0.48–1.04)0.077
G vs. A0.83 (0.67–1.02)0.072
TRAF3rs121472540.709 (0.62–0.82)<0.001Dominant
G/G630 (49.1)911 (50.5)1 (—)0.644
A/G536 (41.7)712 (39.5)1.09 (0.93–1.28)0.271
A/A118 (9.2)180 (10.0)0.97 (0.75–1.27)0.846
G/G vs. A/G+A/A1.07 (0.92–1.24)0.380
G/G+A/G vs. A/A0.97 (0.85–1.10)0.611
G vs. A1.03 (0.92–1.15)0.660

NOTE: All analyses are adjusted for age (continuous), gender, and region. Differences in the overall number may be due to failure in genotyping. For each SNP, we present the result of analyses of heterozygotes vs. homozygotes for the common allele, homozygotes for the rare allele vs. homozygotes for the common allele, dominant model, recessive model, and per-allele model. The model corresponding to the association reported in the original publication for each SNP is underlined.

  • aFor this SNP, samples collected in Italy were already published and therefore omitted from the analysis.

  • bFor this SNP, samples collected in Italy and Hungary were already published and therefore omitted from the analysis. Samples from Poland were out of HWE and therefore omitted as well.

  • cThe original studies were conducted only in women (8, 9).