Table 2.

Associations between selected SNPs and multiple myeloma risk in the IMMEnSE consortium

		IMMEnSE					Original study
Gene	SNP	Cases N (%)	Controls N (%)	OR (95% CI)	P	P_trend	Best OR (95% CI)	P	Inheritance model
SERPINE1	rs2227667						0.39^c (0.24–0.64)	0.0002	Dominant
	A/A	762 (59.2)	1,080 (59.6)	1 (—)	—	0.930
	A/G	457 (35.5)	623 (34.4)	1.00 (0.85–1.17)	0.981
	G/G	68 (5.3)	109 (6.0)	0.83 (0.60–1.15)	0.257
	A/A vs. A/G+G/G			0.97 (0.84–1.13)	0.717
	A/A+A/G vs. G/G			0.91 (0.77–1.07)	0.251
	A vs. G			0.95 (0.84–1.08)	0.460
CCR7	rs3136685						0.38^c (0.22–0.64)	0.0004	Dominant
	G/G	907 (70.2)	1,275 (70.2)	1 (—)	—	0.650
	A/G	342 (26.5)	486 (26.8)	1.03 (0.87–1.22)	0.719
	A/A	43 (3.3)	54 (3.0)	1.17 (0.77–1.80)	0.458
	G/G vs. A/G+A/A			1.04 (0.89–1.23)	0.588
	G/G+A/G vs. A/A			1.08 (0.87–1.33)	0.479
	G vs. A			1.05 (0.91–1.21)	0.486
HGF	rs17501108						2.75^c (1.69–4.48)	4.6 × 10⁻⁵	Dominant
	G/G	984 (77.2)	1,366 (76.6)	1 (—)	—	0.017
	G/T	274 (21.5)	386 (21.7)	1.03 (0.86–1.24)	0.718
	T/T	16 (1.3)	30 (1.7)	0.74 (0.40–1.39)	0.352
	G/G vs. G/T+T/T			1.01 (0.85–1.21)	0.894
	G/G+G/T vs. T/T			0.86 (0.63–1.17)	0.340
	G vs. T			0.99 (0.84–1.16)	0.865
BAX	rs1042265						0.40^c (0.21–0.78)	0.007	Dominant
	C/C	1,076 (83.4)	1,469 (81.5)	1 (—)	—	0.799
	C/T	194 (15.0)	317 (17.6)	0.85 (0.70–1.04)	0.120
	T/T	20 (1.6)	16 (0.9)	1.89 (0.96–3.74)	0.065
	C/C vs. C/T+T/T			0.90 (0.74–1.09)	0.293
	C/C+C/T vs. T/T			1.39 (0.99–1.96)	0.055
	C vs. T			0.96 (0.80–1.45)	0.648
CASP9	rs7516435						2.59^c (1.30–5.15)	0.007	Recessive
	A/A	623 (49.2)	895 (49.7)	1 (—)	—	0.725
	A/G	534 (42.1)	724 (40.3)	1.05 (0.90–1.23)	0.514
	G/G	110 (8.7)	179 (10.0)	0.91 (0.70–1.19)	0.511
	A/A vs. A/G+G/G			1.03 (0.88–1.19)	0.730
	A/A+A/G vs. G/G			0.94 (0.83–1.07)	0.388
	A vs. G			0.99 (0.89–1.11)	0.905
MTHFR	rs1801133						1.27 (1.02–1.58)	—	Dominant (meta)
	G/G	554 (43.8)	767 (42.7)	1 (—)	—	0.721
	A/G	525 (41.5)	787 (43.8)	0.91 (0.78–1.07)	0.267
	A/A	185 (14.7)	243 (13.5)	0.96 (0.77–1.21)	0.757
	G/G vs. A/G+A/A			0.92 (0.80–1.07)	0.312
	G/G+A/G vs. A/A			1.00 (0.90–1.12)	0.929
	G vs. A			0.96 (0.86–1.07)	0.500
mEH	rs2234922						5.81 (1.27–35.7)	0.01	Recessive
	A/A	860 (67.0)	1,150 (63.4)	1 (—)	—	0.635
	A/G	369 (28.7)	596 (32.8)	0.86 (0.74–1.02)	0.081
	G/G	55 (4.3)	70 (3.8)	1.14 (0.78–1.66)	0.502
	A/A vs. A/G+G/G			0.89 (0.76–1.04)	0.155
	A/A+A/G vs. G/G			1.09 (0.91–1.31)	0.356
	A vs. G			0.94 (0.83–1.07)	0.378
MTR	rs1805087						2.31 (1.38–3.87)	0.001	Dominant
	A/A	858 (67.3)	1,201 (66.2)	1 (—)	—	0.974
	A/G	372 (29.2)	549 (30.3)	0.97 (0.83–1.14)	0.734
	G/G	45 (3.5)	63 (3.5)	1.18 (0.78–1.77)	0.430
	A/A vs. A/G+G/G			0.99 (0.85–1.16)	0.916
	A/A+A/G vs. G/G			1.09 (0.89–1.33)	0.402
	A vs. G			1.01 (0.88–1.16)	0.852
IL1β	rs16944^a						0.057 (0.02–0.18)	0.0001	Log-additive
	G/G	471 (44.1)	686 (43.6)	1 (—)	—	0.522
	A/G	461 (43.2)	718 (45.7)	0.90 (0.76–1.07)	0.240
	A/A	136 (12.7)	169 (10.7)	1.11 (0.86–1.45)	0.427
	G/G vs. A/G+A/A			0.94 (0.80–1.11)	0.476
	G/G+A/G vs. A/A			1.08 (0.96–1.22)	0.212
	G vs. A			1.00 (0.89–1.13)	0.944
TNF-α	rs1800629^b						0.58 (0.39–0.87)	0.01	Log-additive
	G/G	478 (75.9)	859 (72.7)	1 (—)	—	0.187
	A/G	143 (22.7)	289 (24.5)	0.88 (0.70–1.12)	0.317
	A/A	9 (1.4)	33 (2.8)	0.48 (0.22–1.05)	0.066
	G/G vs. A/G+A/A			0.84 (0.67–1.06)	0.152
	G/G+A/G vs. A/A			0.71 (0.48–1.04)	0.077
	G vs. A			0.83 (0.67–1.02)	0.072
TRAF3	rs12147254						0.709 (0.62–0.82)	<0.001	Dominant
	G/G	630 (49.1)	911 (50.5)	1 (—)	—	0.644
	A/G	536 (41.7)	712 (39.5)	1.09 (0.93–1.28)	0.271
	A/A	118 (9.2)	180 (10.0)	0.97 (0.75–1.27)	0.846
	G/G vs. A/G+A/A			1.07 (0.92–1.24)	0.380
	G/G+A/G vs. A/A			0.97 (0.85–1.10)	0.611
	G vs. A			1.03 (0.92–1.15)	0.660

NOTE: All analyses are adjusted for age (continuous), gender, and region. Differences in the overall number may be due to failure in genotyping. For each SNP, we present the result of analyses of heterozygotes vs. homozygotes for the common allele, homozygotes for the rare allele vs. homozygotes for the common allele, dominant model, recessive model, and per-allele model. The model corresponding to the association reported in the original publication for each SNP is underlined.

↵^aFor this SNP, samples collected in Italy were already published and therefore omitted from the analysis.
↵^bFor this SNP, samples collected in Italy and Hungary were already published and therefore omitted from the analysis. Samples from Poland were out of HWE and therefore omitted as well.
↵^cThe original studies were conducted only in women (8, 9).