Table 2.

Susceptibility loci associated with higher risk of gastric cancer identified in GWAS

SNPs by nearest gene (locus)StudyEthnicitySubtypeCase/controlAllele-specific OR (95% CI)P
PSCA (8q24.3)
 rs2294008 (T>C)Sakamoto et al. (136)Japanese749/7501.58 (1.35–1.85)6.3 × 10−9
Diffuse925/1,3961.67 (1.47–1.90)2.2 × 10−15
Intestinal599/1,3961.29 (1.11–1.49)6.0 × 10−4
KoreanDiffuse454/3901.91 (1.57–2.33)6.3 × 10−11
Intestinal417/3901.37 (1.12–1.69)0.0017
Abnet et al. (138)ChineseCardia1,213/3,3020.53
Noncardia917/3,3021.27 (1.09–1.47)1.63 × 10−3
Shi et al. (137)ChineseNoncardia4,294/5,8821.36 (NR)2.1 × 10−7
 rs2976392 (A>G)Sakamoto et al. (136)Japanesea749/7501.62 (1.38–1.89)1.1 × 10−9
Diffuse926/1,3971.71 (1.50–1.94)1.5 × 10−16
Intestinal926/1,3971.29 (1.12–1.49)5.0 × 10−4
KoreanDiffuse449/3901.90 (1.56–2.33)8.0 × 10−11
Intestinal416/3901.37 (1.12–1.68)0.0017
Shi et al. (137)ChineseNoncardia4,294/5,8821.35 (NR)3.7 × 10−7
MUC1 (1q22)
 rs4072037 (A>G)Abnet et al. (138)ChineseCardia1,213/3,3020.75 (0.62–0.87)9.5 × 10−5
Noncardia917/3,3020.72 (0.62–0.85)5.7 × 10−5
Total2,240/3,3020.75 (0.67–0.84)4.2 × 10−7
Shi et al. (137)ChineseNoncardia4,294/5,8820.73 (NR)1.0 × 10−4
 rs4460629 (C>T)Abnet et al. (138)ChineseCardia1,213/3,3020.74 (0.64–0.86)1.3 × 10−4
Noncardia917/3,3020.75 (0.64–0.88)5.4 × 10−4
Total2,240/3,3020.75 (0.67–0.85)2.3 × 10−6
 rs2070803 (A>G)Sakamoto et al. (136)bJapanesea749/7501.62 (1.33–1.98)1.2 × 10−6
 rs2075570 (G>A)Sakamoto et al. (136)bJapanesea749/7501.65 (1.34–2.02)9.2 × 10−7
PLCE1 (10q23)
 rs2274223 (A>G)Wang et al. (139)ChineseCardia2,766/11,0131.55 (1.45–1.66)1.7 × 10−39
Abnet et al. (138)ChineseCardia1,213/3,3021.57 (1.40–1.76)4.2 × 10−15
Noncardia917/3,3021.02 (0.86–1.22)0.15
 rs3765524 (C>T)Abnet et al. (138)ChineseCardia1,213/3,3021.56 (1.40–1.75)7.4 × 10−15
Noncardia917/3,3021.03 (0.87–1.22)0.16
 rs3781264 (T>C)Abnet et al. (138)ChineseCardia1,213/3,3021.60 (1.41–1.81)1.1 × 10−13
Noncardia917/3,3021.18 (0.97–1.42)0.25
 rs11187842 (C>T)Abnet et al. (138)ChineseCardia1,213/3,3021.63 (1.42–1.87)7.1 × 10−12
Noncardia917/3,3021.17 (0.97–1.42)0.26
 rs753724 (G>T)Abnet et al. (138)ChineseCardia1,213/3,3021.63 (1.42–1.87)8.0 × 10−12
Noncardia917/3,3021.19 (0.99–1.44)0.16
C20orf54 (20p13)
 rs13042395 (C>T)Shi et al. (137)ChineseNoncardia4,294/5,8820.80 (NR)6.9 × 10−4
Wang et al. (139)ChineseCardia2,766/11,0130.91 (0.85–0.97)3.0 × 10−3
PRKAA1, PTGER4 (5p13.1)
 rs13361707 (T>C)Shi et al. (137)ChineseNoncardia4,294/5,8821.41 (1.32–1.49)7.6 × 10−29
ZBTB20 (3q13.31)
 rs9841504 (C>G)Shi et al. (137)ChineseNoncardia4,294/5,8820.76 (0.69–0.83)1.7 × 10−9

Abbreviation: NR, not reported.

  • aOnly participants included in a part of the study (stage II of the screening study).

  • bAnother gene in the original paper was mentioned as the nearest gene. Further fine mapping showed that the SNP was located in MUC1 gene (140). Meta-analysis of the results from Japanese and Korean populations in this study showed more significant associations between rs2075570 (OR = 1.71; 2.3 × 10−12) and rs2070803 (OR = 1.71; 4.3 × 10−13) and gastric cancer (140).