Table 3.

Genes associated with breast cancer risk at P < 0.05 in gene-based analyses

GenesNumber of variantsVariantsDistance to index SNP (bp)PPconditionala
EFEMP25p.Pro9Thr, p.Thr312Ala, p.His292Tyr, p.Glu261Lys, p.Ile259Val61,2710.00210.0020
FBXO185p.Val15Leu, p.His33Arg, p.Pro88Leu, p.Val552Ile, p.Ile981Phe50,3050.00820.0082
KLHL263p.Val109Leu, p.Arg115Gln, p.Tyr531Phe207,3910.03030.0260
OR2A126p.Tyr34His, p.Thr76Ala, p.Met181Thr, p.Val183Ile, p.Ala223Thr, p.Ser264Asn−282,6290.0498NA
RNASEH2C1p.Arg145Leu−86,9850.03890.0398
GFBR28p.Ser46Arg, p.Val191Ile, p.Arg193Trp, p.Thr206Met, p.Asp247Val, p.Arg313Gln, p.Thr315Met, p.Arg403His−18,2250.0447NA
TRIP134p.Val82Ile, p.Ile99Val, p.Gly173Glu, p.Ile196Val−384,7370.02380.0237
VTI1A2p.Asn40Asp, p.Leu104Pro−475,8380.04290.0424
  • aConditional to the corresponding GWAS index SNP.