Table 4.

Geometric mean (95% CI) of angiogenesis biomarkers at baseline and 12 month, stratified by change in percent body fat and adjusted for age

Baseline12-MonthsDifference
Fat changesNMean (95% CI)NMean (95% CI)Change (%)PaPb
VEGF (pg/mL)Control84419 (367–479)161421 (384–460)1.1 (0.3)Ref.
Gained any fat21391 (318—481)42380 (327—442)11.1 (−2.8)0.48Ref.
Lost <1.85%e30338 (267—427)60347 (295—408)9.2 (2.7)0.240.11
Lost ≥1.85%31267 (215—332)62265 (228—308)2.3 (−0.8)0.950.61
(Pc = 0.63)(Pd = 0.74)
PEDF (μg/mL)Control8411.4 (10.9–12.0)16111.7 (11.3–12.2)0.3 (2.8)Ref.
Gained any fat2112.1 (11.2–13.1)4212.3 (11.5–13.1)0.2 (1.4)0.75Ref.
Lost <1.85%c3011.5 (10.7–12.3)6011.3 (10.8–11.8)0.2 (−2.0)0.140.32
Lost ≥1.85%3111.2 (10.5–12.1)6210.4 (9.9–10.9)0.8 (−7.5)0.0020.013
(Pc = 0.002)(Pd = 0.013)
PAI-1 (ng/mL)Control805.4 (4.8–6.1)1575.6 (5.1–6.1)0.2 (3.3)Ref.
Gained any fat225.1 (4.0–6.5)445.7 (4.8–6.8)0.6 (11.6)0.39Ref.
Lost <1.85%c295.4 (4.5–6.6)585.1 (4.5–5.8)0.3 (−5.9)0.320.13
Lost ≥1.85%304.7 (3.9–5.8)604.0 (3.6–4.5)0.7 (−14.5)0.030.019
(Pc = 0.03)(Pc = 0.02)
OPN (ng/mL)Control8057.9 (54.8–61.2)15757.1 (55.1–59.2)0.8 (−1.4)Ref.
Gained any fat2263.1 (56.7–70.3)4456.2 (52.4–60.2)6.9 (−11.0)0.02Ref.
Lost <1.85%c2959.0 (54.8–63.4)5859.4 (56.7–62.3)0.4 (0.7)0.540.011
Lost ≥1.85%3057.4 (53.1–62.2)6056.7 (53.4–60.2)0.7 (−1.3)0.980.03
(Pc = 0.78)(Pd = 0.05)
  • aTesting difference in change from baseline to 12 months in biomarkers compared with controls.

  • bTesting difference in change from baseline to 12 months in biomarkers compared with “gained any percent body fat,” excluding controls.

  • cTesting for a trend in change from baseline to 12 months in biomarkers from controls through “lost most percent body fat.”

  • dTesting for a trend in change from baseline to 12 months in biomarkers from “gained some body fat” through “lost most percent body fat.”

  • e1.85% corresponds to median levels of percentage of fat lost.