Associations between OBS and markers of oxidative stress and inflammation
| Biomarkersa | ||||
|---|---|---|---|---|
| OBS | Highc | Lowc | OR (95% CI)b | P trend |
| FIP | ||||
| Interval 1 (OBS, 2–9) | 51 | 20 | 1.0 | <0.01 |
| Interval 2 (OBS, 10–16) | 91 | 68 | 0.50 (0.25–1.01) | |
| Interval 3 (OBS, 17–24) | 17 | 27 | 0.25 (0.10–0.65) | |
| Continuous | 159 | 115 | 0.87 (0.81–0.94) | |
| FOP | ||||
| Interval 1 (OBS, 2–9) | 33 | 45 | 1.0 | <0.01 |
| Interval 2 (OBS, 10–16) | 107 | 77 | 2.01 (1.13–3.75) | |
| Interval 3 (OBS, 17–24) | 36 | 19 | 3.48 (1.51–8.02) | |
| Continuous | 176 | 141 | 1.10 (1.03–1.17) | |
| CRP | ||||
| Interval 1 (OBS, 2–9) | 56 | 31 | 1.0 | <0.01 |
| Interval 2 (OBS, 10–16) | 108 | 87 | 0.57 (0.31–1.04) | |
| Interval 3 (OBS, 17–24) | 19 | 39 | 0.21 (0.09–0.49) | |
| Continuous | 183 | 157 | 0.88 (0.82–0.94) | |
↵aEach biomarker was dichotomized into “high” and “low” based on study- and sex-specific median values among controls.
↵bAdjusted for age, race, sex, BMI, total energy intake, plasma cholesterol, and family history of colorectal cancer in a first-degree relative, hormone replacement therapy (among women), dietary fiber, physical activity, and study (MAP I or MAP II).
↵cTotal numbers of subjects in the models differ due to missing covariate or biomarker data.