Table 4.

Associations between OBS and markers of oxidative stress and inflammation

Biomarkersa
OBSHighcLowcOR (95% CI)bP trend
FIP
 Interval 1 (OBS, 2–9)51201.0<0.01
 Interval 2 (OBS, 10–16)91680.50 (0.25–1.01)
 Interval 3 (OBS, 17–24)17270.25 (0.10–0.65)
Continuous1591150.87 (0.81–0.94)
FOP
 Interval 1 (OBS, 2–9)33451.0<0.01
 Interval 2 (OBS, 10–16)107772.01 (1.13–3.75)
 Interval 3 (OBS, 17–24)36193.48 (1.51–8.02)
Continuous1761411.10 (1.03–1.17)
CRP
 Interval 1 (OBS, 2–9)56311.0<0.01
 Interval 2 (OBS, 10–16)108870.57 (0.31–1.04)
 Interval 3 (OBS, 17–24)19390.21 (0.09–0.49)
Continuous1831570.88 (0.82–0.94)
  • aEach biomarker was dichotomized into “high” and “low” based on study- and sex-specific median values among controls.

  • bAdjusted for age, race, sex, BMI, total energy intake, plasma cholesterol, and family history of colorectal cancer in a first-degree relative, hormone replacement therapy (among women), dietary fiber, physical activity, and study (MAP I or MAP II).

  • cTotal numbers of subjects in the models differ due to missing covariate or biomarker data.