Table 4.

HRs and 95% CIs for the association between alcohol consumption and the risk of a second breast cancer diagnosis: WISC DCIS cohort, 1997–2010

All second breast cancer diagnosesInvasive second breast cancer diagnoses
Prediagnosis (N = 1,925)Postdiagnosis (N = 1,903)bPrediagnosis (N = 1,925)Postdiagnosis (N = 1,903)b
Second diagnosisHR (95% CI)aPtrendcHR (95% CI)aPtrendcSecond diagnosisHR (95% CI)aPtrendcHR (95% CI)aPtrendc
Total alcohol (drinks/wk)
 No alcohol271.00 (Ref.)0.881.00 (Ref.)0.0291.00 (Ref.)0.181.00 (Ref.)0.15
 >0–<2800.98 (0.62–1.53)1.28 (0.59–2.78)250.95 (0.43–2.08)1.38 (0.37–5.47)
 2–<7350.91 (0.54–1.53)1.76 (0.64–4.80)151.23 (0.52–2.90)1.40 (0.14–4.35)
 7+201.04 (0.58–1.88)2.59 (0.61–11.0)81.21 (0.45–3.22)1.74 (0.17–9.68)
 Continuous per 1 drink/wk1621.02 (0.99–1.05)1.03 (0.94–1.11)571.04 (0.99–1.09)1.05 (0.90–1.23)
  • aAdjusted for age at diagnosis, menopausal status, mode of detection, postmenopausal hormone use, tamoxifen use, year of diagnosis, tumor size, tumor grade, remaining lifestyle factors, and prediagnosis levels of each lifestyle factor.

  • bPostdiagnosis results are additionally adjusted for prediagnosis levels of each lifestyle factor.

  • cP is for linear trend across categories.