Table 3.

Associations between biomarkers of interest and state of residency

AlaskaArizona
Biomarker(N = 42)(N = 53)Pd
Continuous markersa
 P5340.3 (38.8)18.5 (31.1)0.004
 MIB-121.6 (21.8)27.7 (22.5)0.190
 Cyclin D121.5 (28.0)25.3 (22.7)0.476
Ordinal markersb
 EGFR0.15 (0.58)0.53 (0.82)0.015
 BCL-22.07 (1.30)2.17 (1.07)0.686
 HER20.81 (1.13)1.32 (1.01)0.023
Binary markersc
 ER0.722
  Negative9 (21)13 (25)
  Positive33 (79)40 (75)
 PR0.095
  Negative12 (29)24 (45)
  Positive30 (71)29 (55)
 HER2 (2 or 3+)0.087
  Negative33 (79)33 (62)
  Positive9 (21)20 (38)
 HER2 (3+)0.968
  Negative35 (83)44 (83)
  Positive7 (17)9 (17)
 ER/PR/HER2 (2 or 3+)0.930
  Triple negative5 (12)6 (11)
  Positive37 (88)47 (89)
 ER/PR/HER2 (3+)0.849
  Triple negative5 (12)7 (13)
  Positive37 (88)46 (87)
  • aValues for continuous markers are based on percent staining and range from 0 to 100. Summary statistics provided are mean (SD).

  • bValues for ordinal markers are based on staining intensity and take on values of 0, 1, 2, or 3. Summary statistics provided are mean (SD).

  • cBinary markers are classified as negative or positive. Summary statistics provided are number positive (percent).

  • dUnadjusted P value from two-sample t test (for continuous or ordinal markers) or χ2 test (for binary markers). Age-adjusted analyses and randomization tests yielded similar results.