Table 2.

HRs and 95% CIs for the association between PSMA expression in tumor tissue and lethal prostate cancer

PSMA quartile (Q)
Q1 (low)Q2Q3Q4 (high)Ptrenda
All patients
N lethal events15242234
N censored210202204191
 Person-time, y3,0612,9713,0322,825
 Model 1b1.001.64 (0.85,3.14)1.55 (0.80,3.01)2.42 (1.31,4.48)<0.01
 Model 2c1.001.17 (0.60,2.30)1.11 (0.56,2.22)1.01 (0.52,1.93)0.76
Nonadvanced staged
N lethal events410816
N censored169156136141
 Person-time, y2,3932,2771,9582,007
 Model 1b1.002.43 (0.75,7.83)2.42 (0.73,8.07)4.34 (1.43,13.12)<0.01
 Model 2c1.001.86 (0.55,6.30)2.06 (0.60,7.06)1.74 (0.53,5.73)0.61
Advanced stagee
N lethal events10141418
N censored41466849
 Person-time, y6616931,074810
 Model 1b1.001.35 (0.59,3.09)1.17 (0.50,2.74)1.65 (0.74,3.64)0.27
 Model 2c1.000.90 (0.38,2.11)0.85 (0.34,2.09)0.78 (0.34,1.78)0.55
Gleason score 2–7
N lethal events5131116
N censored194180171146
 Person-time, y2,8082,5912,5042,109
 Model 1b1.003.05 (1.08,8.65)2.62 (0.91,7.59)4.63 (1.68,12.73)<0.01
 Model 2c1.002.64 (0.90,7.73)2.02 (0.67,6.11)2.11 (0.72,6.17)0.51
Gleason score 8–10
N lethal events10111118
N censored16223345
 Person-time, y253380528716
 Model 1b1.000.51 (0.21,1.27)0.60 (0.24,1.47)0.53 (0.23,1.25)0.39
 Model 2c1.000.56 (0.22,1.45)0.78 (0.30,2.03)0.59 (0.24,1.40)0.47
  • aWald test modeling the median expression values for each PSMA quartile.

  • bAdjusted for age at diagnosis (continuous) and tissue microarray.

  • cIn addition adjusted for Gleason score (2 to 6, 3 + 4, 4 + 3, 8–10), and PSA at diagnosis (<4, 4 to <10, ≥10 ng/mL, missing).

  • dTumor stage T1–T2, N0–Nx, M0–Mx.

  • eTumor stage T3–T4, or N1 or M1.