Table 2.

ORs and 95% CIs of primary liver cancer based on plasma adiponectin levels

Tertile
Plasma levelLowMiddleHighPa
Total adiponectin
 Range, μg/mL≤3.40 for men and ≤5.32 for women3.41–5.68 for men and 5.33–8.50 for women>5.68 for men and >8.50 for women
 No. cases/controls17/6036/5637/61
 OR (95% CI)1.00 (reference)2.23 (1.14–4.38)2.25 (1.11–4.55)0.03
 Multivariable OR (95% CI)b1.00 (reference)2.59 (1.22–5.50)3.30 (1.45–7.53)<0.01
 Multivariable OR (95% CI)c + alcohol and coffee consumption, ALT level1.00 (reference)2.44 (0.60–9.95)3.76 (1.06–13.42)0.04
HMW adiponectin
 Range, μg/mL≤1.05 for men and ≤2.37 for women1.06–2.56 for men and 2.38–4.30 for women>2.56 for men and >4.30 for women
 No. cases/controls17/6037/5836/59
 OR (95% CI)1.00 (reference)2.39 (1.18–4.86)2.38 (1.15–4.93)0.03
 Multivariable OR (95% CI)b1.00 (reference)2.77 (1.26–6.06)3.41 (1.50–7.73)<0.01
 Multivariable OR (95% CI)c + alcohol and coffee consumption, ALT level1.00 (reference)2.89 (0.76–11.07)3.85 (0.99–15.05)0.06
  • aLinear trends were tested using the exposure categories as ordinal variables.

  • bAdjusted for BMI (<18.5, 18.5–21.9, 22.0–24.9, ≥25.0 kg/m2) and diabetes (yes or no).

  • cFurther adjusted for alcohol consumption (never, past, <150, 150 to <450, ≥450 g/wk ethanol), coffee consumption (almost never, 1 time/wk to <1 cup/d, ≥1 cup/d), and ALT level (<30, 30–69, ≥70 IU/L).