Table 3.

Prospective rates of breast cancer incidence and ORs in those FDRs testing negative for BRCA1/2

SeriesNumberYears follow-up (rate per 1,000)Breast cancersExpected cancersOR (95% CI)
All tested negative from family ascertainmentBRCA12623,217 (2.17)73.951.77 (0.71–3.65)
BRCA22382,634 (5.3)143.064.57 (2.50–7.67)
Family History Clinic group from family ascertainmentBRCA1 negative1111,141.8 (1.76)2
BRCA2 negative1341,189.9 (5.9)71.454.82 (2.63–8.09)
BRCA2 untested52490.500.79
Adjusted BRCA2 including untested1621,454.8 (4.8)71.983.535 (1.42–7.29)
From negative genetic test dateBRCA12621,456.8 (2.7)43.801.05 (0.28–2.70)
BRCA2238852 (4.7)42.011.99 (0.54–5.10)