Table 3.

Correlation of PSMA protein expression in prostate tumor tissue with other tumor biomarkers

All patientsNonadvanced stageaAdvanced stagebGleason score 2–7Gleason score 8–10
Partial Spearman rank correlation coefficientsc
Proliferation index
N867613252707160
 Median [Q1, Q3]0.13 [0, 0.55]0.14 [0, 0.56]0.12 [0, 0.49]0.11 [0, 0.46]0.23 [0.03, 1.01]
r−0.00002−0.0010.0090.004−0.127
P1.000.980.890.930.12
Apoptosis index
N716507208589127
 Median [Q1, Q3]0.50 [0, 2.00]0.50 [0, 2.00]0.50 [0, 2.00]0.50 [0, 2.00]0.50 [0, 2.00]
r−0.005−0.0040.0150.038−0.166
P0.890.930.830.370.07
VDR protein expression
N812567243658154
 Median [Q1, Q3]29.1 [13.0, 45.4]31.6 [14.9, 47.7]24.0 [8.9, 42.8]30.9 [14.3, 47.7]21.0 [7.0, 37.7]
r−0.084−0.098−0.010−0.066−0.049
P0.020.020.870.090.56
AR protein expression
N860612246704156
 Median [Q1, Q3]117.7 [112.3, 123.0]117.3 [112.3, 123.0]117.7 [111.0, 123.0]115.0 [111.0, 123.0]117.7 [112.3, 123.0]
r−0.103−0.099−0.123−0.100−0.144
P<0.010.010.06<0.010.08
Markers of angiogenesisd
 Microvessel density
  N41427513933282
  Median [Q1, Q3]67.1 [55.0, 95.0]65.3 [53.0, 92.5]74.3 [58.0, 100.0]66.6 [52.9, 93.0]75.5 [59.0, 102.7]
  r0.1620.1650.1680.1670.011
  P<0.01<0.010.05<0.010.93
 Vessel area
  N41527613933283
  Median [Q1, Q3]466.5 [357.7, 654.7]486.5 [370.5, 664.4]430.2 [304.6, 648.7]485.0 [371.9, 671.6]420.0 [301.3, 567.4]
  r−0.168−0.165−0.198−0.147−0.150
  P<0.01<0.010.02<0.010.19
 Vessel diameter
  N41527613933283
  Median [Q1, Q3]24.2 [21.4, 27.8]24.4 [21.9, 27.7]23.3 [20.3, 27.9]24.5 [21.8, 28.3]22.6 [19.8, 26.2]
  r−0.141−0.130−0.192−0.120−0.119
  P<0.010.030.030.030.30
 Vessel irregularitye
  N41527613933283
  Median [Q1, Q3]4.0 [3.2, 4.8]3.9 [3.1, 4.7]4.1 [3.3, 4.9]3.9 [3.2, 4.7]4.1 [3.4, 5.1]
  r0.1000.0260.2500.0570.124
  P0.040.68<0.010.310.28
ANCOVAc
ERG expression
 Absent, N43432211134886
  Adjusted mean PSMA64.267.564.859.072.6
 Present, N44630114436680
  Adjusted mean PSMA49.351.750.344.059.1
P<0.01<0.01<0.01<0.010.02
  • aTumor stage T1–T2, N0–Nx, M0–Mx.

  • bTumor stage T3–T4 or N1 or M1.

  • cAdjusted for age at diagnosis and tissue microarray.

  • dMeasured in HPFS cohort only.

  • eHigher score indicates more irregularity.