Table 3.

ORs and 95% CIs of primary liver cancer associated with plasma adiponectin levels by subgroups

Total adiponectinHMW adiponectin
LowHighLowHigh
Range, μg/mL≤4.33 for men and ≤6.12 for women>4.33 for men and >6.12 for women≤1.59 for men and ≤2.74 for women>1.59 for men and >2.74 for women
All participants
No. cases/controls30/8960/8836/8954/88
Mutivariable OR (95% CI)a1.00 (reference)3.08 (1.62–5.86)1.00 (reference)2.03 (1.09–3.78)
Sex
 MenNo. cases/controls24/6138/6130/6132/61
Mutivariable OR (95% CI)a1.00 (reference)2.43 (1.11–5.34)1.00 (reference)1.27 (0.60–2.65)
 WomenNo. cases/controls6/2822/276/2822/27
Mutivariable OR (95% CI)a1.00 (reference)9.90 (1.96–50.14)1.00 (reference)9.93 (1.97–50.18)
Pb0.270.05
Hepatitis virus infectious status
 HBVNo. cases/controls5/116/106/115/10
Mutivariable OR (95% CI)a1.00 (reference)1.46 (0.18–11.48)1.00 (reference)1.15 (0.12–10.70)
 HCVNo. cases/controls25/7854/7830/7849/78
Mutivariable OR (95% CI)a1.00 (reference)3.18 (1.58–6.39)1.00 (reference)2.13 (1.08–4.18)
Pb0.870.97
BMI
 <25.0 kg/m2No. cases/controls15/6641/8020/6836/78
Mutivariable OR (95% CI)c1.00 (reference)3.01 (1.42–6.38)1.00 (reference)1.95 (0.97–3.89)
 ≥25.0 kg/m2No. cases/controls15/2319/816/2118/10
Mutivariable OR 95% CI)c1.00 (reference)3.88 (1.10–13.70)1.00 (reference)2.60 (0.72–9.44)
Pb0.410.47
Diabetes
 NoNo. cases/controls17/6343/7521/6439/74
Mutivariable OR (95% CI)c1.00 (reference)3.14 (1.45–6.80)1.00 (reference)1.98 (0.96–4.06)
 YesNo. cases/controls13/2617/1315/2515/14
Mutivariable OR (95% CI)c1.00 (reference)3.28 (0.89–12.08)1.00 (reference)1.90 (0.52–6.96)
Pb0.730.84
  • aAdjusted for BMI and diabetes using a conditional logistic model.

  • bStatistical interaction between adiponectin levels and stratified variables was tested with a likelihood ratio test.

  • cWe used an unconditional logistic model adjusted for age, sex, public health center area, fasting status at blood collection, hepatitis virus infectious status, baseline menopausal status, BMI, and diabetes except for stratified variable.