Table 1.

High-risk BRCA1/BRCA2-negative cancer patients tested for PALB2 mutations

GroupPatients; NMean age at dg; yBRCAPRO; mean valueMutations; N (%)
Familial cases (N = 330)
 HBC families23547.20.1613 (5.5)
 HBOC families9047.80.350
 HOC families540.20.350
Nonfamilial cases (N = 79)
 Male breast cancer2264.70.141 (4.5)
 Bilateral breast cancer before 503943.70.301 (2.6)
 Tumor duplicity, breast cancer + ovarian cancer1853.70.331 (5.6)
Total40916 (3.9)

Abbreviations: HBOC, hereditary breast and ovarian cancer; HOC, hereditary ovarian cancer.