Table 1.

Descriptive information of the 49 network CEC

CEC name (abbreviation)Initiation yearCancer sitesStudy participantsComponent groupsaCountriesbWebsite URL
International Consortium of Bladder Cancer (ICBC)2005Bladder13,090 cases, 16,537 controls23BEL, CHN, DEU, DNK, ESP, FRA, GBR, ITA, JPN, NLD, ROK, SWE, TUR, USAhttp://icbc.cancer.gov/
Brain Tumor Epidemiology Consortium (BTEC)2003Brain∼6,500 cases2AUT, DNK, GBR, SWE, USAhttp://epi.grants.cancer.gov/btec/index.html
GLIOGENE2007Brain4,269 cases; 2,834 controls15DNK, GBR, ISR, SWE, USAhttp://www.gliogene.org/
Pediatric Brain Tumor Consortium (PBTC; refs. 40, 41)1999Brain1,330 controls12USAhttp://www.pbtc.org/
Asia Breast Cancer Consortium (ABCC; ref. 42)2008Breast17,153 cases, 16,943 controls10CHN, JPN, ROK, TWN, USANone
Breast Cancer and the Environment Research Program (BCERP)2003BreastCohort of 1,200 young girls4USAhttp://www.bcerc.org/index.htm
Breast Cancer Association Consortium (BCAC)2005Breast77,741 cases, 83,362 controls69AUS, BEL, BLR, CAN, CHN, CYP, DEU, DNK, ESP, FIN, FRA, GBR, HKG, IRL, ITA, JPN, MEX, MYS, NLD, NOR, POL, PRT, ROK, RUS, SGP, SWE, THA, TWN, USAhttp://www.srl.cam.ac.uk/consortia/bcac/
Breast Cancer Consortium for Outcomes and Survival (BC2OS)2007Breast48,000 cases32AUS, CHN, GRC, MYS, NGA, NLD, NOR, ROK, SWE, TUR, USANone
Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA; ref. 43)2005BreastMore than 10,000 BRCA1 carriers and 5,000 BRCA2 carriers59AUS, AUT, BEL, CAN, COL, CZE, DEU, DNK, ESP, FIN, FRA, GBR, GRC, HKG, HUN, ISL, ISR, ITA, LTU, LVA, MYS, NLD, PAK, POL, ROK, PRT, RUS, SGP, SWE, USA, ZAFhttp://www.srl.cam.ac.uk/consortia/cimba/
African-American Breast Cancer Consortium2008Breast6,671 cases, 15,314 controls4USANone
Prevention and Observation of Surgical Endpoints and Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (PROSE-Modifier Studies)2000Breast5,187 BRCA1/2 carriers23AUT, GBR, NLD, USAhttp://www.cceb.upenn.edu/pages/prose/index.html
Women, Cancer and Radiation Exposure (WECARE)2002Breast700 asynchronous bilateral BC cases; 1400 unilateral BC cases20DNK, NOR, SWE, USAhttp://skiweb.mskcc.org/WECARE/front.html
Breast Cancer Family Registry(BCFR; refs. 35, 44)1995Breast, Ovary14,605 cases, 51,801 controls6AUS, CAN, USAhttp://epi.grants.cancer.gov/CFR/about_breast.html
Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium (ENIGMA; ref. 45)2009Breast, Ovary, others3,504 BRCA1 UV/VUS carrier families; 5,717 BRCA2 UV/VUS carrier families43AUS, AUT, BRA, CAN, CZE, DNK, ESP, FIN, FRA, GBR, GRC, HKG, ITA, MYS, NLD, SWE, USAhttp://enigmaconsortium.org/
Breast and Prostate Cancer Cohort Consortium (BPC3; ref. 46)2003Breast, ProstateAt least 10,500 PC cases, 8,500 BC cases; 22,700 controls10DNK, DEU, ESP, FRA, GBR, GRC, ITA, NLD, NOR, SWE, USAhttp://epi.grants.cancer.gov/BPC3/
Asia Colorectal Cancer Consortium (ACCC; ref. 47)2009ColonAt least 7,456 cases, 11,671 controls6CHN, JPN, ROK, USANone
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)2008Colon∼20,000 cases, ∼20,000 controls18CAN, DEU, FRA, USAhttp://www.fhcrc.org/content/public/en/labs/phs/projects/cancer-prevention/projects/gecco.html
Molecular Epidemiology of Colorectal Cancer (MECC)1998Colon3,330 cases, 3,330 controls2ISR, USAhttp://sitemaker.umich.edu/gruber.lab/gruber.research/mecc
Colon Cancer Family Registry (CCFR; ref. 36)1997Colon16,438 cases, 48,300 controls6AUS, CAN, ESP, NZL, USAhttp://epi.grants.cancer.gov/CFR/about_colon.html
Epidemiology of Endometrial Cancer Consortium (E2C2; ref. 48)2006Endometrium4,523 cases, 25,217 controls from case-control studies; 5,818 cases from cohort studies36AUS, BEL, CAN, CHE, CHN, GBR, GRC, ITA, NLD, NOR, POL, SWE, USAhttp://epi.grants.cancer.gov/eecc/
Asian Barrett's Consortium2008EsophagusNot available2BRN, CHN, IDN, IND, JPN, MYS, ROK, SGP, THA, TWN, VNMNone
International Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)2005Esophagus1,585 EA cases, 2,736 BE cases; 4,274 controls18AUS, CAN, FRA, GBR, IRL, NLD, SWE, USAhttp://beacon.tlvnet.net/
International Head and Neck Cancer Epidemiology Consortium (INHANCE; ref. 49)2004Head, Neck30,059 cases, 40,949 controls43BRA, CAN, CHE, CHN, DEU, FRA, IND, ITA, JPN, NLD, PRI, USAhttp://inhance.iarc.fr/index.php
Childhood Leukemia International Consortium (CLIC)2006Hematopoietic13,000 cases, 21,000 controls22AUS, BRA, CAN, CRI, DEU, EGY, FRA, GBR, GRC, ITA, NZL, USAhttps://ccls.berkeley.edu/clic/
Chronic Lymphocytic Leukemia Research Consortium (CRC)2006Hematopoietic5,300 cases8GBR, USAhttp://cll.ucsd.edu/
International Lymphoma Epidemiology Consortium (InterLymph; ref. 50)2001Hematopoietic13,000 cases, 16,000 controls18AUS, CAN, CZE, DEU, DNK, EGY, ESP, FIN, FRA, GBR, IRL, ISR, ITA, JAM, JOR, SWE, USAhttp://epi.grants.cancer.gov/InterLymph/
International Multiple Myeloma Consortium (IMMC)2007Hematopoietic2,870 cases10AUS, CAN, GBR, IRL, ITA,None
Genetic Epidemiology of Lung Cancer (GELCC)1999Lung2,000 cases, 2,000 controls5USAhttp://www.eh.uc.edu/gelcc/
International Lung Cancer Consortium (ILCCO)2004Lung59,530 cases, 68,974 controls; 795,000 cohort participants56CAN, CHN, DEU, DNK, ESP, FRA, GBR, GRC, ISL, ISR, ITA, JPN, NLD, NOR, ROK, SGP, SWE, TWN, USAhttp://ilcco.iarc.fr/
Genes, Environment and Melanoma (GEM; ref. 51)1999Melanoma∼3,700 single or multiple melanoma cases8AUS, CAN, ITA, USAhttp://gemstudy.org/main/index.html
Melanoma Genetics Consortium (GenoMEL)1997Melanoma5,327 cases22ARG, AUS, BRA, CHL, COL, ESP, FRA, GBR, ISR, ITA, LVA, MEX, NLD, POL, SVN, SWE, URY, USAhttp://www.genomel.org/
African-Caribbean Cancer Consortium (AC3; ref. 52)2006Multi-site1,677 cases, 2,638 controls54AIA, BHS, BRB, CYM, GHA, JAM, KEN, KNA, MTQ, NGA, NZL, TTO, USAhttp://www.ac-ca-consortium.org/
Asia Cohort Consortium (ACC; refs. 53, 54)2004Multi-site1,185,000 cohort participants (40)21BGD, CHN, IND, JPN, MYS, ROK, SGP, THA, TWNhttp://www.asiacohort.org/Pages/Default.aspx
Cancer Genetics Network (CGN; ref. 55)1998Multi-site26,271 enrollees with personal or family history of cancer14USAhttp://www.cancergen.org/
Cohort Consortium (CoCo)2000Multi-site>4,000,000 cohort participants; 481,371 cases50AUS, CAN, CHN, DEU, DNK, ESP, FIN, FRA, GBR, GRC, IRN, ITA, JPN, NLD, NOR, SGP, SWE, USAhttp://epi.grants.cancer.gov/Consortia/cohort.html
International Childhood Cancer Cohort Consortium (I4C; ref. 56)2005Multi-siteCohort of ∼1,000,000 births; 801 incident cases11AUS, CHN, CHN, DNK, ESP, FRA, GBR, ISR, ITA, JPN, NOR, ROK, USAhttp://www.nationalchildrensstudy.gov/research/internationalinvolvement/pages/default.aspx
Latin American Cancer Epidemiology Consortium (LACE)2008Multi-site17,842 cases; 22,709 controls8ARG, BRA, COL, ESP, GBR, MEX, PRI, PRT, USANone
Radiogenomics Consortium (RGC; ref. 57)2009Multi-site14,790 cases87AUS, BEL, CAN, CHE, DEU, DNK, ESP, FRA, GBR, ISR, ITA, JPN, NLD, POL, ROK, TWN, USANone
Ovarian Cancer Association Consortium (OCAC; ref. 58)2005Ovary13,548 cases; 19,913 controls47AUS, BEL, CAN, CHN, DEU, DNK, FIN, JPN, MYS, NLD, NOR, POL, USAhttp://www.srl.cam.ac.uk/consortia/ocac/index.html
Ovarian Cancer Cohort Consortium (OC3)2009Ovary4,152 cases22AUS, BEL, CAN, CHE, DEU, DNK, FRA, GBR, JPN, NLD, NOR, POL, SGP, USANone
Pacific Ovarian Cancer Research Consortium (POCRC)1999OvaryScreening cohort of >1,000 women6USAhttp://www.pocrc.org/
Pancreatic Cancer Case Control Consortium (PANC4)2006Pancreas10,991 cases, 16,358 controls16CAN, AUS, CHN, GBR, ITA, USAhttp://panc4.org/
Pancreatic Cancer Cohort Consortium (PanScan)2006Pancreas>1,900,000 cohort participants; 4,620 incident cases; 780 retrospective cases20AUS, CHN, DEU, DNK, ESP, FRA, GBR, GRC, ITA, NLD, NOR, SWE, USAhttp://epi.grants.cancer.gov/PanScan/
Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE; ref. 59)2002Pancreas11,587 cases; 7,417 familial controls6CAN, USAhttp://mayoresearch.mayo.edu/petersen_lab/epidemiology.cfm
Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1 and BRCA2 mutation carriers and controls (IMPACT; refs. 60–62)2005Prostate205 BRCA1/2 carriers, 95 non-carriers; 11 cases39AUS, CAN, DNK, ESP, GBR, ISR, ITA, MYS, NOR, POL, SVK, SVN, SWE, USAhttp://www.impact-study.co.uk/
International Consortium for Prostate Cancer Genetics (ICPCG; refs. 63, 64)1996Prostate6,400 cases and 6,000 controls from 2550 PCA families15AUS, CAN, DEU, FIN, FRA, GBR, NOR, SWE, USAhttps://www.icpcg.org/
Men of African Descent and Prostate Cancer (MADCaP; ref. 65)2007Prostate4,703 cases, 5,327 controls22BHS, BRB, GBR, GHA, GUY, NGA, SEN, TTO, UGA, USA, ZAFhttp://epi.grants.cancer.gov/madcap/index.html
Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL; ref. 66)2007ProstateAt least 26,055 cases and 25,256 controls66AUS, BEL, BGR, CAN, CHE, CHN, DEU, DNK, ESP, FIN, FRA, GBR, IND, IRL, JPN, MYS, NOR, POL, PRT, ROU, SWE, THA, USAhttp://www.srl.cam.ac.uk/consortia/practical/index.html
Prostate Cancer Transatlantic Consortium (CaPTC)2005Prostate385 cases8BHS, NGA, USAhttp://epi.grants.cancer.gov/captc/
  • aComponent groups can include individual studies, institutions, sites, and regional centers.

  • bThree-letter country codes: AIA, Anguilla; ARG, Argentina; AUS, Australia; AUT, Austria; BEL, Belgium; BGD, Bangladesh; BGR, Bulgaria; BHS, Bahamas; BLR, Belarus; BRA, Brazil; BRB, Barbados; BRN, Brunei; CAN, Canada; CHE, Switzerland; CHL, Chile; CHN, China; COL, Colombia; CRI, Costa Rica; CYM, Cayman Islands; CYP, Cyprus; CZE, Czech Republic; DEU, Germany; DNK, Denmark; EGY, Egypt; ESP, Spain: FIN, Finland; FRA, France; GBR, United Kingdom; GHA, Ghana; GRC, Greece; GUY, Guyana; HKG, Hong Kong; HUN, Hungary; IDN, Indonesia; IND, India; IRL, Ireland; IRN, Iran; ISL, Iceland; ISR, Israel; ITA, Italy; JAM, Jamaica; JOR, Jordan; JPN, Japan; KEN, Kenya; KNA, St Kitt and Nevis; LTU, Lithuania; LVA, Latvia; MEX, Mexico; MTQ, Martinique; MYS, Malaysia; NGA, Nigeria; NLD, Netherlands; NOR, Norway; NZL, New Zealand; PAK, Pakistan; POL, Poland; PRI, Puerto Rico; PRT, Portugal; ROK, South Korea; ROU, Romania; RUS, Russia; SEN, Senegal; SGP, Singapore; SVK, Slovakia; SVN, Slovenia; SWE, Sweden; THA, Thailand; TTO, Trinidad and Tobago; TUR, Turkey; TWN, Taiwan; UGA, Uganda; URY, Uruguay; USA, United States; VNM, Viet Nam; ZAF, South Africa.