Table 1.

Descriptive information of the 49 network CEC

CEC name (abbreviation)Initiation yearCancer sitesStudy participantsComponent groupsaCountriesbWebsite URL
International Consortium of Bladder Cancer (ICBC)2005Bladder13,090 cases, 16,537 controls23BEL, CHN, DEU, DNK, ESP, FRA, GBR, ITA, JPN, NLD, ROK, SWE, TUR, USA
Brain Tumor Epidemiology Consortium (BTEC)2003Brain∼6,500 cases2AUT, DNK, GBR, SWE, USA
GLIOGENE2007Brain4,269 cases; 2,834 controls15DNK, GBR, ISR, SWE, USA
Pediatric Brain Tumor Consortium (PBTC; refs. 40, 41)1999Brain1,330 controls12USA
Asia Breast Cancer Consortium (ABCC; ref. 42)2008Breast17,153 cases, 16,943 controls10CHN, JPN, ROK, TWN, USANone
Breast Cancer and the Environment Research Program (BCERP)2003BreastCohort of 1,200 young girls4USA
Breast Cancer Association Consortium (BCAC)2005Breast77,741 cases, 83,362 controls69AUS, BEL, BLR, CAN, CHN, CYP, DEU, DNK, ESP, FIN, FRA, GBR, HKG, IRL, ITA, JPN, MEX, MYS, NLD, NOR, POL, PRT, ROK, RUS, SGP, SWE, THA, TWN, USA
Breast Cancer Consortium for Outcomes and Survival (BC2OS)2007Breast48,000 cases32AUS, CHN, GRC, MYS, NGA, NLD, NOR, ROK, SWE, TUR, USANone
Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA; ref. 43)2005BreastMore than 10,000 BRCA1 carriers and 5,000 BRCA2 carriers59AUS, AUT, BEL, CAN, COL, CZE, DEU, DNK, ESP, FIN, FRA, GBR, GRC, HKG, HUN, ISL, ISR, ITA, LTU, LVA, MYS, NLD, PAK, POL, ROK, PRT, RUS, SGP, SWE, USA, ZAF
African-American Breast Cancer Consortium2008Breast6,671 cases, 15,314 controls4USANone
Prevention and Observation of Surgical Endpoints and Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (PROSE-Modifier Studies)2000Breast5,187 BRCA1/2 carriers23AUT, GBR, NLD, USA
Women, Cancer and Radiation Exposure (WECARE)2002Breast700 asynchronous bilateral BC cases; 1400 unilateral BC cases20DNK, NOR, SWE, USA
Breast Cancer Family Registry(BCFR; refs. 35, 44)1995Breast, Ovary14,605 cases, 51,801 controls6AUS, CAN, USA
Evidence-based Network for the Interpretation of Germline Mutant Alleles Consortium (ENIGMA; ref. 45)2009Breast, Ovary, others3,504 BRCA1 UV/VUS carrier families; 5,717 BRCA2 UV/VUS carrier families43AUS, AUT, BRA, CAN, CZE, DNK, ESP, FIN, FRA, GBR, GRC, HKG, ITA, MYS, NLD, SWE, USA
Breast and Prostate Cancer Cohort Consortium (BPC3; ref. 46)2003Breast, ProstateAt least 10,500 PC cases, 8,500 BC cases; 22,700 controls10DNK, DEU, ESP, FRA, GBR, GRC, ITA, NLD, NOR, SWE, USA
Asia Colorectal Cancer Consortium (ACCC; ref. 47)2009ColonAt least 7,456 cases, 11,671 controls6CHN, JPN, ROK, USANone
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)2008Colon∼20,000 cases, ∼20,000 controls18CAN, DEU, FRA, USA
Molecular Epidemiology of Colorectal Cancer (MECC)1998Colon3,330 cases, 3,330 controls2ISR, USA
Colon Cancer Family Registry (CCFR; ref. 36)1997Colon16,438 cases, 48,300 controls6AUS, CAN, ESP, NZL, USA
Epidemiology of Endometrial Cancer Consortium (E2C2; ref. 48)2006Endometrium4,523 cases, 25,217 controls from case-control studies; 5,818 cases from cohort studies36AUS, BEL, CAN, CHE, CHN, GBR, GRC, ITA, NLD, NOR, POL, SWE, USA
Asian Barrett's Consortium2008EsophagusNot available2BRN, CHN, IDN, IND, JPN, MYS, ROK, SGP, THA, TWN, VNMNone
International Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)2005Esophagus1,585 EA cases, 2,736 BE cases; 4,274 controls18AUS, CAN, FRA, GBR, IRL, NLD, SWE, USA
International Head and Neck Cancer Epidemiology Consortium (INHANCE; ref. 49)2004Head, Neck30,059 cases, 40,949 controls43BRA, CAN, CHE, CHN, DEU, FRA, IND, ITA, JPN, NLD, PRI, USA
Childhood Leukemia International Consortium (CLIC)2006Hematopoietic13,000 cases, 21,000 controls22AUS, BRA, CAN, CRI, DEU, EGY, FRA, GBR, GRC, ITA, NZL, USA
Chronic Lymphocytic Leukemia Research Consortium (CRC)2006Hematopoietic5,300 cases8GBR, USA
International Lymphoma Epidemiology Consortium (InterLymph; ref. 50)2001Hematopoietic13,000 cases, 16,000 controls18AUS, CAN, CZE, DEU, DNK, EGY, ESP, FIN, FRA, GBR, IRL, ISR, ITA, JAM, JOR, SWE, USA
International Multiple Myeloma Consortium (IMMC)2007Hematopoietic2,870 cases10AUS, CAN, GBR, IRL, ITA,None
Genetic Epidemiology of Lung Cancer (GELCC)1999Lung2,000 cases, 2,000 controls5USA
International Lung Cancer Consortium (ILCCO)2004Lung59,530 cases, 68,974 controls; 795,000 cohort participants56CAN, CHN, DEU, DNK, ESP, FRA, GBR, GRC, ISL, ISR, ITA, JPN, NLD, NOR, ROK, SGP, SWE, TWN, USA
Genes, Environment and Melanoma (GEM; ref. 51)1999Melanoma∼3,700 single or multiple melanoma cases8AUS, CAN, ITA, USA
Melanoma Genetics Consortium (GenoMEL)1997Melanoma5,327 cases22ARG, AUS, BRA, CHL, COL, ESP, FRA, GBR, ISR, ITA, LVA, MEX, NLD, POL, SVN, SWE, URY, USA
African-Caribbean Cancer Consortium (AC3; ref. 52)2006Multi-site1,677 cases, 2,638 controls54AIA, BHS, BRB, CYM, GHA, JAM, KEN, KNA, MTQ, NGA, NZL, TTO, USA
Asia Cohort Consortium (ACC; refs. 53, 54)2004Multi-site1,185,000 cohort participants (40)21BGD, CHN, IND, JPN, MYS, ROK, SGP, THA, TWN
Cancer Genetics Network (CGN; ref. 55)1998Multi-site26,271 enrollees with personal or family history of cancer14USA
Cohort Consortium (CoCo)2000Multi-site>4,000,000 cohort participants; 481,371 cases50AUS, CAN, CHN, DEU, DNK, ESP, FIN, FRA, GBR, GRC, IRN, ITA, JPN, NLD, NOR, SGP, SWE, USA
International Childhood Cancer Cohort Consortium (I4C; ref. 56)2005Multi-siteCohort of ∼1,000,000 births; 801 incident cases11AUS, CHN, CHN, DNK, ESP, FRA, GBR, ISR, ITA, JPN, NOR, ROK, USA
Latin American Cancer Epidemiology Consortium (LACE)2008Multi-site17,842 cases; 22,709 controls8ARG, BRA, COL, ESP, GBR, MEX, PRI, PRT, USANone
Radiogenomics Consortium (RGC; ref. 57)2009Multi-site14,790 cases87AUS, BEL, CAN, CHE, DEU, DNK, ESP, FRA, GBR, ISR, ITA, JPN, NLD, POL, ROK, TWN, USANone
Ovarian Cancer Association Consortium (OCAC; ref. 58)2005Ovary13,548 cases; 19,913 controls47AUS, BEL, CAN, CHN, DEU, DNK, FIN, JPN, MYS, NLD, NOR, POL, USA
Ovarian Cancer Cohort Consortium (OC3)2009Ovary4,152 cases22AUS, BEL, CAN, CHE, DEU, DNK, FRA, GBR, JPN, NLD, NOR, POL, SGP, USANone
Pacific Ovarian Cancer Research Consortium (POCRC)1999OvaryScreening cohort of >1,000 women6USA
Pancreatic Cancer Case Control Consortium (PANC4)2006Pancreas10,991 cases, 16,358 controls16CAN, AUS, CHN, GBR, ITA, USA
Pancreatic Cancer Cohort Consortium (PanScan)2006Pancreas>1,900,000 cohort participants; 4,620 incident cases; 780 retrospective cases20AUS, CHN, DEU, DNK, ESP, FRA, GBR, GRC, ITA, NLD, NOR, SWE, USA
Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE; ref. 59)2002Pancreas11,587 cases; 7,417 familial controls6CAN, USA
Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1 and BRCA2 mutation carriers and controls (IMPACT; refs. 60–62)2005Prostate205 BRCA1/2 carriers, 95 non-carriers; 11 cases39AUS, CAN, DNK, ESP, GBR, ISR, ITA, MYS, NOR, POL, SVK, SVN, SWE, USA
International Consortium for Prostate Cancer Genetics (ICPCG; refs. 63, 64)1996Prostate6,400 cases and 6,000 controls from 2550 PCA families15AUS, CAN, DEU, FIN, FRA, GBR, NOR, SWE, USA
Men of African Descent and Prostate Cancer (MADCaP; ref. 65)2007Prostate4,703 cases, 5,327 controls22BHS, BRB, GBR, GHA, GUY, NGA, SEN, TTO, UGA, USA, ZAF
Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL; ref. 66)2007ProstateAt least 26,055 cases and 25,256 controls66AUS, BEL, BGR, CAN, CHE, CHN, DEU, DNK, ESP, FIN, FRA, GBR, IND, IRL, JPN, MYS, NOR, POL, PRT, ROU, SWE, THA, USA
Prostate Cancer Transatlantic Consortium (CaPTC)2005Prostate385 cases8BHS, NGA, USA
  • aComponent groups can include individual studies, institutions, sites, and regional centers.

  • bThree-letter country codes: AIA, Anguilla; ARG, Argentina; AUS, Australia; AUT, Austria; BEL, Belgium; BGD, Bangladesh; BGR, Bulgaria; BHS, Bahamas; BLR, Belarus; BRA, Brazil; BRB, Barbados; BRN, Brunei; CAN, Canada; CHE, Switzerland; CHL, Chile; CHN, China; COL, Colombia; CRI, Costa Rica; CYM, Cayman Islands; CYP, Cyprus; CZE, Czech Republic; DEU, Germany; DNK, Denmark; EGY, Egypt; ESP, Spain: FIN, Finland; FRA, France; GBR, United Kingdom; GHA, Ghana; GRC, Greece; GUY, Guyana; HKG, Hong Kong; HUN, Hungary; IDN, Indonesia; IND, India; IRL, Ireland; IRN, Iran; ISL, Iceland; ISR, Israel; ITA, Italy; JAM, Jamaica; JOR, Jordan; JPN, Japan; KEN, Kenya; KNA, St Kitt and Nevis; LTU, Lithuania; LVA, Latvia; MEX, Mexico; MTQ, Martinique; MYS, Malaysia; NGA, Nigeria; NLD, Netherlands; NOR, Norway; NZL, New Zealand; PAK, Pakistan; POL, Poland; PRI, Puerto Rico; PRT, Portugal; ROK, South Korea; ROU, Romania; RUS, Russia; SEN, Senegal; SGP, Singapore; SVK, Slovakia; SVN, Slovenia; SWE, Sweden; THA, Thailand; TTO, Trinidad and Tobago; TUR, Turkey; TWN, Taiwan; UGA, Uganda; URY, Uruguay; USA, United States; VNM, Viet Nam; ZAF, South Africa.