Table 2.

Characteristics of prostate cancer cases across quartiles of PTEN expression in the HPFS (1986–2010) and PHS (1983–2010) Prostate Tumor Cohort

Mean percent area of PTEN staining
naOverallQ1Q2Q3Q4Ptrend
Mean percent area of PTEN+, mean (SD)8050.23 (0.21)0.04 (0.02)0.11 (0.03)0.23 (0.05)0.53 (0.17)
Age at diagnosis, mean (SD), y80565.9 (6.3)65.9 (6.4)65.3 (6.1)66.2 (6.2)66.5 (6.3)0.2b
Baseline BMI, mean (SD), kg/m280524.9 (3.0)24.8 (2.6)25.0 (3.9)24.9 (2.8)24.9 (2.4)0.8b
Tumor stage, n (%)805
 pT1b-pT2N0M0577 (71.7)128 (67.0)143 (68.4)154 (76.6)152 (74.5)
 pT3N0M0195 (24.7)54 (28.3)57 (27.3)41 (20.4)43 (21.1)
 pT4/N1/M133 (4.1)9 (4.7)9 (4.3)6 (3.0)9 (4.4)0.06c
Gleason grade, n (%)804
 2–6183 (22.8)36 (19.0)46 (22.0)45 (22.4)56 (27.5)
 7493 (61.3)117 (61.6)131 (62.7)129 (64.2)116 (56.9)
 8–10128 (15.9)37 (19.5)32 (15.3)27 (13.4)32 (15.7)0.049c
PSA at diagnosis, n (%)680
 <479 (11.6)18 (11.1)16 (9.0)24 (14.6)21 (11.9)
 4–10398 (58.5)94 (58.0)110 (62.2)92 (56.1)102 (57.6)
 >10203 (29.9)50 (30.9)51 (28.8)48 (29.3)54 (30.5)0.7c
Angiogenesis—CD34 staining351
 Vessel aread, mean (SD), μm2549.2 (265.6)502.0 (246.9)556.4 (248.6)596.4 (319.7)530.4 (233.0)0.3b
 Irregularity of vessel lumene, mean (SD)3.87 (1.00)3.88 (0.99)3.67 (0.93)3.89 (1.06)4.01 (1.00)0.3b
Apoptosis—TUNEL assay
 Percentage of stained area, mean (SD)6692.2 (4.5)1.6 (3.6)2.1 (4.2)1.8 (3.4)3.3 (6.3)0.002b
Cell proliferation—Ki-67 staining
 Percentage of positive nuclei, mean (SD)7730.73 (2.6)0.81 (2.8)0.48 (0.99)0.59 (1.4)1.04 (3.9)0.07b
  • aMissing data if N is not equal to 805.

  • bPtrend was calculated using ANOVA.

  • c Ptrend was calculated from the Mantel–Haenszel statistic.

  • dSmaller vessels are more angiogenic.

  • eIrregular vessels are more angiogenic, a score of 1.0 indicates a perfect circle.