Table 2.

Therapeutic exposures by drug category and CRT

Therapeutic exposureN (%)
CRTa43 (13.5)
Alkylating agents184 (57.7)
Anthracyclines183 (57.4)
Antimetabolites, non-intrathecal administration route136 (42.6)
Antimetabolites, intrathecal administration route131 (41.1)
Enzymes110 (34.5)
Platinum44 (13.8)
Plant alkyloids209 (65.5)
Steroids141 (44.2)
Topoisomerase inhibitors70 (21.9)
  • aWhole brain without spine (n = 12), whole brain + spine (n = 14), partial brain (n = 17, including any CNS-directed radiation that was not whole brain).