Table 6.

Multivariate mixed model tests for heterogeneity of relationships between molecular signaturesc and epidemiologic risk factors adjusted for age at diagnosis for 106 advanced-stage HGS ovarian cancersd

C1C2C3C4C5C6
VariableβSEβSEβSEβSEβSEβSEMixed model P
Race
 Non-African AmericanReferentbReferentReferentReferentbReferentbReferentb0.003
 African American−0.9790.272−0.4610.2780.1150.1970.8640.2791.1120.2810.6060.165
Age at menarche
 ≥12ReferentReferentReferentReferentReferentReferent0.559
 0–<12−0.2720.244−0.2610.239−0.0820.1670.2560.2460.4480.2530.1170.149
Menopausal status
 PremenopausalReferentReferentReferentReferentReferentReferent0.733
 Postmenopausal−0.0150.276−0.0300.270−0.2980.1870.0370.2790.1540.2890.0130.168
Number of live births
 NoneReferentReferentReferentReferentReferentReferent0.344
 1–20.0650.260−0.1250.261−0.2420.1800.0510.2640.1190.274−0.0240.161
 3–40.1500.289−0.1010.289−0.0430.200−0.1100.2930.1380.3040.0580.178
 ≥51.1970.5380.1020.539−0.2950.372−0.9870.547−0.9490.566−0.3960.332
Age at last pregnancy, y
 25–29ReferentReferentReferentReferentReferentReferent0.534
 14–24−0.4910.274−0.3470.270−0.1720.1650.4560.2740.6660.2890.2480.165
 30–34−0.1870.299−0.0970.295−0.1940.1800.2420.3000.3360.3150.0430.181
 ≥350.1430.276−0.1460.2720.0260.166−0.1330.276−0.0610.291−0.0090.167
Breasfeeding, mo
 NeverReferentReferentbReferentReferentReferentaReferenta0.024
 <6−0.3240.2810.3850.253−0.0950.1730.3230.287−0.0750.281−0.1330.160
 6–12−0.2260.4110.1170.370−0.0830.2530.2060.420−0.0160.411−0.0610.234
 ≥12−0.6440.314−0.9570.2830.0980.1930.3510.3211.0630.3140.5490.178
Duration of oral contraceptive use, y
 NeverReferentaReferentReferentReferentReferentReferent0.071
 0–<1−0.1780.2980.6520.297−0.2330.2120.2100.301−0.2910.326−0.1120.188
 1–<5−0.2660.2470.1200.2460.0480.1760.2310.2500.1670.2710.2210.156
 ≥5+0.4520.2360.0240.235−0.2280.168−0.4180.239−0.0590.2590.0710.149
Doctor diagnosis of infertility
 NoReferentReferentReferentReferentReferentReferent0.736
 Yes0.4280.2960.0020.2920.0290.204−0.4200.299−0.3410.311−0.2110.180
BMI (kg/m2)
 25–<30ReferentReferentReferentReferentReferentReferent0.221
 13–<250.1010.2360.2220.2330.0290.1630.0470.239−0.3790.251−0.2220.145
 30–<35−0.3150.2950.3090.2920.0960.2040.5410.299−0.0840.313−0.0280.181
 ≥350.3730.3230.0040.3190.3820.223−0.1940.327−0.4360.343−0.1130.198
Tubal ligation
 NoReferentReferentReferentReferentReferentReferent0.435
 Yes0.2500.2120.3400.206−0.0240.146−0.1910.215−0.3880.220−0.1320.129
Endometriosis
 NoReferentReferentReferentaReferentReferentReferent0.311
 Yes0.2300.3780.0090.371−0.5350.254−0.3070.3820.0680.396−0.1090.230
Smoking status
 Never smokedReferentReferentReferentReferentReferentReferent0.194
 Current smoker−0.1780.2720.3610.2640.0190.1860.2330.274−0.0030.2840.0050.166
 Ex-smoker0.0870.214−0.0900.2080.0400.147−0.0970.2160.2170.2240.0510.130
Family history of breast or ovarian cancers
 NoReferentReferentReferentReferentReferentReferenta0.034
 Yes0.3610.2210.2910.217−0.2460.151−0.2400.225−0.2500.233−0.2720.133
  • Multivariable regression analysis significance levels: aP < 0.05, bP < 0.01.

  • cC1: high stromal response, C2: immunoreactive, C3: well differentiated, C4: low stromal response, C5: mesenchymal/undifferentiated, C6: endometrioid.

  • dRegression coefficients are the expected difference in the signature, measured in SDs, associated with unit change in the covariate.