Table 3.

Stratified analysis representing SNPs from the Metabochip platform with P < 10−4 comparing high-grade prostate cancer cases (n = 427) versus controls (n = 906) and high-grade prostate cancer cases (n = 427) versus low-grade prostate cancer cases (n = 444) from NMHS

SNPChrPositionOn gene/nearby genesEA/RAEAF controlsEAF casesORSEPN
High-grade vs. controls
 rs3855680192857475ZNF57,a ZNF556, ZNF555, ZNF77G/T0.450.360.690.095.08 × 10−51,333
 rs94092269121890597MIR147A, CDK5RAP2, DBC1A/C0.090.131.720.135.21 × 10−51,333
 CHR10:959186761095918676PLCE1,a TBC1D12, PIPSLT/G0.060.040.370.255.28 × 10−51,325
 CHR3:85876066385876066CADM2,a VGLL3C/G0.110.171.660.125.69 × 10−51,333
 rs37864181819994876CABYR,a OSBPL1A, TTC39C, LAMA3C/T0.180.251.520.118.50 × 10−51,330
SNPChrPositionOn gene/nearby genesEA/RAEAF LGEAF HGORSEPN
High-grade vs. low-grade
 rs72527871935400475ZNF536, URI1, POP4, TSHZ3C/T0.220.311.680.122.32 × 10−5871
 CHR17:302946071730294607CCT6B,a LIG3G/A0.310.401.530.104.59 × 10−5871
 rs109025811599081396ASB7, LRRK1, ALDH1A3T/C0.400.501.520.105.77 × 10−5871
 rs111328594171857089HSP90AA6P, GALNTL6, AADATA/G0.360.270.640.116.81 × 10−5871
 rs1355625378439962ROBO1, ROBO2A/G0.480.390.670.105.90 × 10−5871

NOTE: Results adjusted for age and 10 principal components.

Abbreviations: Chr, chromosome; EA, effect allele; EAF, effect allele frequency; HG, high-grade; LG, low-grade; RA, referent allele.

  • aSNP is on the gene.