Table 4.

Multivariate mixed model tests for heterogeneity of relationships between molecular signaturesd and age at diagnosis and tumor characteristicse

C1C2C3C4C5C6
VariableβSEβSEβSEβSEβSEβSEMixed model P
All invasive ovarian cancer cases
 Age at diagnosis, y
  20–49ReferentReferentReferentReferentbReferentReferent0.0008
  50–590.1530.184−0.2670.193−0.0650.154−0.3330.1900.4110.1970.1530.155
  60–690.0520.188−0.0780.197−0.2560.157−0.2290.1940.3140.2010.1620.158
  ≥700.5750.238−0.2750.249−0.0320.198−0.8580.2450.1830.254−0.0680.200
 Histologic subtype
  SerousReferentReferentReferentReferentReferentReferentc<0.0001
  Clear cell0.5490.348−0.6300.3650.7230.290−0.6470.3580.0750.3720.6570.292
  Endometrioid−0.3460.210−0.1500.2200.0230.1750.2280.2160.2950.2241.2610.176
  Mucinous−0.2980.372−0.1600.390−0.1330.3100.3610.3830.4230.3981.1310.312
  Other−0.2470.212−0.3670.2220.0580.1770.1850.2180.5690.2270.7830.178
 Primary cancer site
  OvaryReferentbReferentReferentReferentbReferentbReferent0.0011
  Peritoneal0.8600.2280.3110.239−0.2430.190−0.6870.234−0.7840.243−0.2850.191
 Stage at diagnosis
  TNM stage I/IIReferentaReferentReferentReferentReferentReferenta0.0061
  TNM stage III/IV0.4650.203−0.0810.213−0.1520.169−0.2700.209−0.0780.217−0.3750.170
 Tumor grade
  Poor/undifferentiatedReferentReferentcReferentcReferentReferentReferentb<0.0001
  Moderately differentiated0.0230.157−0.6720.1640.4770.131−0.1570.1610.3650.1680.2250.132
 Well differentiated0.0290.217−1.0440.2281.8860.181−0.4540.2240.0910.2320.7030.182
Advanced-stage HGS ovarian cancer cases
 Age at diagnosis, y
  20–49ReferentReferentReferentReferentReferentReferent0.0161
  50–590.0450.2780.0160.264−0.0490.186−0.2140.2880.2860.2840.0460.166
  60–690.0560.2790.1880.265−0.2710.187−0.2390.2890.1570.285−0.0180.167
  ≥700.4360.355−0.4470.3370.2860.237−0.8280.3670.3560.3620.3160.212
 Primary cancer site
  OvaryReferentbReferentaReferentReferentaReferentbReferentb0.0013
  Peritoneal0.8300.2570.5680.244−0.3250.172−0.5890.266−0.9780.262−0.4870.154
 Tumor grade
  Poor/undifferentiatedReferentReferentbReferentbReferentReferentaReferentb0.0003
  Moderately differentiated−0.0910.187−0.7030.1770.4820.125−0.0110.1930.4770.1900.3080.112
  • Multivariable regression analysis significance levels: aP < 0.05; bP < 0.01; cP < 0.0001.

  • dC1: high stromal response, C2: immunoreactive, C3: well differentiated, C4: low stromal response, C5: mesenchymal/undifferentiated, C6: endometrioid.

  • eRegression coefficients are the expected difference in the signature, measured in SDs, associated with unit change in the covariate.