Table 2.

Risk of multiple myeloma associated with alcohol consumption in pooled study population by gender

MaleFemale
Alcohol consumptionCaseControlOR (95% CI)a,bOR (95% CI)a,cCaseControlOR (95% CI)a,bOR (95% CI)a,cPinteraction
Total69936748563541
Never drinker1847471.00 (–)43516331.00 (–)
Ever drinker51529270.72 (0.59–0.89)42119080.81 (0.68–0.95)0.59
 Current25718030.57 (0.45–0.72)20211790.55 (0.45–0.68)
  Currentd28918510.65 (0.52–0.82)22611990.62 (0.51–0.77)
 Former1264491.11 (0.84–1.47)1222641.32 (1.02–1.70)
  Formere944010.90 (0.66–1.24)982441.11 (0.85–1.47)
Currentd drinker frequencyf
T1613170.70 (0.50–0.98)1.00 (–)432790.55 (0.38–0.79)1.00 (–)
T2544120.49 (0.34–0.70)0.74 (0.48–1.12)672960.62 (0.45–0.85)1.01 (0.64–1.59)
T3744610.62 (0.45–0.87)0.95 (0.63–1.41)863480.77 (0.57–1.04)1.22 (0.79–1.91)0.21
Ptrend(0.01)(0.90)(0.23)(0.36)
Currentd drinker durationg
T1635710.64 (0.45–0.92)1.00 (–)373590.51 (0.34–0.75)1.00 (–)
T2955780.71 (0.52–0.96)1.12 (0.73–1.73)934040.76 (0.58–1.01)1.45 (0.91–2.31)
T31226450.61 (0.46–0.81)0.98 (0.61–1.58)954260.57 (0.43–0.75)0.99 (0.59–1.65)0.27
Ptrend(0.001)(0.84)(0.001)(0.86)
Currentd drinker cumulativeh
T1613700.65 (0.46–0.91)1.00 (–)492880.63 (0.44–0.91)1.00 (–)
T2594030.56 (0.40–0.80)0.90 (0.60–1.36)593170.56 (0.41–0.78)0.79 (0.51–1.23)
T3714190.61 (0.44–0.86)1.02 (0.67–1.54)883180.76 (0.57–1.02)0.99 (0.64–1.53)0.53
Ptrend(0.01)(0.87)(0.16)(0.79)

Male tertiles: <8.7, ≤21.4, >21.4.

Female tertiles: <1.6, ≤7.1, >7.1.

Male tertiles: <30, ≤43, >43

Female tertiles: <23, ≤40, >40

Male tertiles: <16,882, ≤48,400, >48,400

Female tertiles: <2,743, ≤12,600, >12,600

  • aAdjusted for age, race, and center.

  • bReference group is never drinkers.

  • cReference group is among drinkers.

  • dIncludes participants who ceased drinking within 2 years prior to completion of questionnaire.

  • eExcludes participants who ceased drinking within 2 years prior to completion of questionnaire.

  • fAverage number of standard drinks per week.

  • gNumber of years consumed.

  • hLifetime number of standard drinks (frequency × duration).