Table 4.

Overall ORs comparing BMI GRSs and WHR GRSs with prostate cancer risk among participants from NMHS

Obesity scoresCases/controlsOR (95% CI)P
BMI GRS
Unweighted BMI allele scorea863/8761.00 (0.97, 1.04)0.94
Weighted BMI allele scoreb863/8761.07 (0.91, 1.25)0.41
WHR GRS
Unweighted WHR allele scorec863/8761.01 (0.97, 1.06)0.52
Weighted WHR allele scored863/8761.10 (0.91, 1.32)0.32

NOTE: All models adjusted for age, BMI, or WHR, respectively, natural log of prostate volume and 10 principal components. Information on prostate volume was missing for 30 controls and 8 cases; results for multivariable analyses are thus based on 876 controls and 863 cases.

  • aUnweighted BMI allele score represents the summation of the number of BMI increasing alleles per individual.

  • bWeighted BMI allele score represents the summation of the number of BMI increasing alleles per individual after weighting with each SNP's respective beta coefficient for BMI increase.

  • cUnweighted WHR allele score represents the summation of the number of WHR increasing alleles per individual.

  • dWeighted WHR allele score represents the summation of the number of WHR increasing alleles per individual after weighting with each SNP's respective beta coefficient for BMI increase; per 0.3 increase in score (weighted WHR score range: 0.19–1.49).