Table 3.

Hazard ratios with 95% Confidence Intervals for smoking status and pack-years of smoking for risk of incident cancer in patients with manifest vascular disease without a history of cancer at baseline

Smoking statusPack-years of smoking
Cancer site (ICD-10 code)NeverFormerCurrent01 to <30≥30
All [excluding non-melanoma skin cancer (C44)]
Men
 No. of patients7292,2521,4317292,3081,375
 No. of events4621013546185160
 Crude model1.00 (reference)1.41 (1.03–1.94)1.29 (0.92–1.80)1.00 (reference)1.18 (0.85–1.63)1.65 (1.19–2.30)
 Adjusted modela1.00 (reference)1.25 (0.91–1.72)1.41 (1.00–1.98)1.00 (reference)1.15 (0.83–1.59)1.56 (1.12–2.16)
Women
 No. of patients464520544464726338
 No. of events344942345734
 Crude model1.00 (reference)1.35 (0.87–2.10)0.93 (0.59–1.46)1.00 (reference)1.04 (0.68–1.59)1.27 (0.79–2.05)
 Adjusted modela1.00 (reference)1.49 (0.95–2.32)1.14 (0.72–1.82)1.00 (reference)1.25 (0.81–1.91)1.46 (0.90–2.37)
Men and women
 No. of patients1,1932,7721,9751,1933,0341,713
 No. of events8025917780242194
 Crude model1.00 (reference)1.36 (1.06–1.75)1.16 (0.89–1.51)1.00 (reference)1.12 (0.87–1.44)1.53 (1.18–1.99)
 Adjusted modela1.00 (reference)1.33 (1.03–1.73)1.37 (1.05–1.80)1.00 (reference)1.21 (0.93–1.56)1.59 (1.22–2.07)
Colon, rectum (C18–C20)
Men and women
 No. of patients1,1932,7721,9751,1933,0341,713
 No. of events113921113426
 Crude model1.00 (reference)1.49 (0.76–2.92)1.00 (0.48–2.09)1.00 (reference)1.15 (0.58–2.26)1.50 (0.74–3.03)
 Adjusted modela1.00 (reference)1.66 (0.82–3.39)1.37 (0.64–2.94)1.00 (reference)1.42 (0.70–2.88)1.77 (0.84–3.73)
Larynx, trachea/bronchus/lung (C32–C34)
Men and women
 No. of patients1,1932,7721,9751,1933,0341,713
 No. of events8515984862
 Crude model1.00 (reference)2.69 (1.28–5.65)3.91 (1.87–8.18)1.00 (reference)2.23 (1.05–4.71)4.95 (2.37–10.32)
 Adjusted modela1.00 (reference)2.65 (1.22–5.78)4.60 (2.13–9.92)1.00 (reference)2.41 (1.11–5.22)5.14 (2.37–11.14)
Breast (C50)
Women
 No. of patients464520544464726338
 No. of events71177162
 Crude model1.00 (reference)1.49 (0.59–3.81)0.73 (0.25–2.08)1.00 (reference)1.41 (0.58–3.41)0.36 (0.07–1.71)
 Adjusted modela1.00 (reference)1.41 (0.52–3.83)0.64 (0.21–1.91)1.00 (reference)1.34 (0.50–3.54)0.35 (0.07–1.69)
Prostate (C61)
Men
 No. of patients7292,2521,4317292,3081,375
 No. of events9412993931
 Crude model1.00 (reference)1.41 (0.68–2.89)1.43 (0.68–3.02)1.00 (reference)1.27 (0.62–2.62)1.65 (0.79–3.47)
 Adjusted modela1.00 (reference)1.21 (0.58–2.50)1.64 (0.77–3.51)1.00 (reference)1.23 (0.59–2.54)1.55 (0.74–3.26)
  • aModel adjusted for age, sex (when not stratified by), BMI, and alcohol use.