Table 2.

Heartburn medication history by heartburn frequency and case–control status

Study subjects having ever experienced heartburna
All LPSCCControls
Heartburn medication historybRareOftenPdifferencecRareOftenPdifferenced
None91 (42.7%)8 (7.2%)<0.001155 (41.2%)7 (4.0%)<0.001
Antacids only63 (29.6%)14 (12.6%)147 (39.1%)36 (20.7%)
PPI or H2 receptor antagonists50 (23.5%)83 (74.8%)52 (13.8%)118 (67.8%)
 Also used antacids18 (8.5%)21 (18.9%)18 (4.8%)35 (20.1%)
 Never used antacids32 (15.0%)62 (55.9%)34 (9.0%)83 (47.7%)
Other medications or home remedies9 (4.2%)6 (5.4%)22 (5.9%)13 (7.5%)

Abbreviation: PPI, proton pump inhibitor.

  • aSubjects with available heartburn medication data but who did not supply heartburn frequency data were excluded from this table.

  • bMedication data were missing for a total of 5 cases (4 rare, 1 often/extreme) and 5 controls (3 rare, 2 often/extreme) with available heartburn frequency data.

  • cFisher's exact test for difference across medication use categories by heartburn frequency among LPSCC cases.

  • dFisher's exact test for difference across medication use categories by heartburn frequency among controls.