Table 1.

Parameters used for estimating transition rates

NotationParameter
TCRC_MAN,aAnnual transition rate from carriage of preclinical CRC to clinically manifest CRC, at age a
TADV_CRC,aAnnual transition rate from carriage of at least one advanced adenoma (but no CRC) to carriage of preclinical CRC, at age a
TNON_ADV,aAnnual transition rate from carriage of at least one nonadvanced adenoma (but no advanced adenoma) to carriage of at least one advanced adenoma, at age a
PARTa and PARTa+1Total number of screening colonoscopy participants at age a in 2003–2009 and age a+1 in 2004–2010, respectively
ADVa and ADVa+1Numbers of participants at age a in 2003–2009 and age a+1 in 2004–2010, respectively, with at least one advanced adenoma (>1 cm in diameter, tubulovillous or villous components, or high-grade dysplasia), but no CRC
NONaNumbers of participants at age a in 2003–2009 with at least one nonadvanced adenoma, but no advanced adenoma or CRC
CRCa and CRCa+1Numbers of participants at age a in 2003–2009 and age a+1 in 2004–2010, respectively, with CRC
SMean sojourn time of CRC, i.e., the mean time a CRC exists before it becomes clinically manifest
PProportion of CRC developing from advanced adenomas according to the adenoma–carcinoma sequence