Table 2.

Effects of 16 weeks of aerobic exercise on estrogen metabolism of WISER participants

Baseline geometric mean (95% CI)P value for baseline differencesFollow-up geometric mean (95% CI)P value for differences in mean change
Estrone, E1, nmol/d
 Exercisers23.1 (19.0–28.2)0.58623.0 (18.9–28.0)0.042
 Controls25.0 (20.3–30.8)23.0 (18.8–28.2)a
Estradiol, E2, nmol/d
 Exercisers7.8 (6.8–8.8)0.7868.3 (7.2–9.5)0.725
 Controls8.0 (7.0–9.1)8.0 (7.2–9.2)
Estriol, E3, nmol/d
 Exercisers21.3 (16.5–27.4)0.96318.6 (14.4–24.2)0.715
 Controls21.1 (16.2–27.5)21.0 (16.0–27.5)
16α-OHE1, nmol/d
 Exercisers2.9 (2.3–3.7)0.3032.6 (2.1–3.4)0.971
 Controls2.5 (1.9–3.1)2.5 (1.9–3.2)
2-OHE1, nmol/d
 Exercisers39.3 (33.7–45.8)0.08444.2 (38.4–50.8)0.098
 Control47.6 (40.5–55.8)45.5 (39.3–52.6)
4-OHE1, nmol/d
 Exercisers2.3 (2.1–2.7)0.6472.4 (2.1–2.7)0.362
 Controls2.4 (2.1–2.8)2.4 (2.1–2.7)
2-OHE2, nmol/d
 Exercisers3.4 (2.4–5.0)0.2093.5 (2.4–5.1)0.194
 Controls2.5 (1.7–3.6)2.9 (1.9–4.2)
4-OHE2, nmol/d
 Exercisers0.7 (0.4–1.0)0.7670.8 (0.5–1.3)0.898
 Controls0.7 (0.5–1.2)0.5 (0.3–0.8)
2-MeOE1, nmol/d
 Exercisers8.2 (6.5–10.4)0.3129.3 (7.4–11.8)0406
 Controls6.9 (5.4–8.8)8.6 (6.8–10.9)
4-MeOE1, nmol/d
 Exercisers1.9 (1.4–2.6)0.5621.7 (1.2–2.4)0.488
 Controls2.2 (1.6–3.0)1.5 (1.1–2.1)
2-MeOE2, nmol/d
 Exercisers7.1 (5.4–9.3)0.2697.0 (5.4–9.1)0.556
 Controls5.8 (4.3–7.6)6.6 (5.1–8.7)
4-MeOE2, nmol/d
 Exercisers1.6 (1.2–2.3)0.2541.5 (1.0–2.1)0.552
 Controls1.2 (0.9–1.8)0.9 (0.7–1.4)
2-OHE1/16α-OHE1
 Exercisers13.4 (10.4–17.2)0.04416.8 (13.1–21.4)b0.045
 Controls19.3 (14.8–25.1)18.5 (14.3–24.0)
2-OHE1/4-OHE1
 Exercisers16.8 (14.8–19.0)0.10418.7 (16.8–20.9)0.123
 Controls19.5 (17.1–22.2)18.9 (16.9–21.2)

NOTE: Values are age- and BMI-adjusted geometric means (95% CI). Follow-up and mean change from baseline comparisons in 2-OHE1 and 2-OHE1/16α-OHE1 were additionally adjusted for baseline values.

  • aP = 0.030 (within-group differences).

  • bP = 0.043 (within-group differences).