Table 2.

Geometric means of biomarkers at baseline and week 6 of treatment period by treatment groups

BaselineWeek 6
BiomarkersNGeometric mean (95% CI)NGeometric mean (95% CI)
Total TNEa
 VLNC Cigarette5455.70 (48.42, 64.07)546.89 (4.26, 11.02)
 Patch5949.90 (43.82, 57.40)5823.10 (14.59, 36.60)
 VLNC Cigarette + Patch5853.52 (46.99, 61.56)5827.39 (17.29, 43.38)
Total cotininea
 VLNC cigarette5417.12 (14.44, 20.09)542.03 (1.20, 3.45)
 Patch5916.78 (14.30, 19.69)595.50 (3.31, 9.13)
 VLNC cigarette + patch5817.99 (15.33, 21.12)587.65 (4.59, 12.76)
Total NNALb
 VLNC cigarette531.20 (1.00, 1.43)520.40 (0.29, 0.55)
 Patch591.29 (1.09, 1.53)590.25 (0.18, 0.34)
 VLNC cigarette + patch571.09 (0.92, 1.30)550.26 (0.19, 0.36)

NOTE: Values are for all subjects from whom data were collected at the visit in question.

  • anmol/mg creatinine.

  • bpmol/mg creatinine.