Table 3.

Association between genetic risk score and ovarian cancer among all women and by environmental factors

	Invasive		Serous		Mucinous		Endometrioid		Clear cell
	OR^a (95% CI)	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b
All women	2.56 (2.14–3.06)		2.50 (2.13–2.94)		2.61 (1.41–4.81)		3.49 (2.18–5.59)		3.11 (1.31–7.39)
Endometriosis
Yes	4.35 (2.09–9.05)		6.50 (3.10–13.63)		2.88 (0.06–143.62)		6.86 (1.32–35.66)		2.03 (0.13–30.77)
No	2.47 (2.02–3.02)	0.14	2.31 (1.93–2.77)	0.01	2.50 (1.24–5.01)	0.94	3.86 (2.24–6.67)	0.52	3.73 (1.31–10.61)	0.68
First-degree family history
Yes	2.48 (0.87–7.08)		3.02 (1.22–7.44)		0.33 (0.00–61.92)		0.22 (0.01–5.00)		—
No	2.51 (2.09–3.01)	0.98	2.44 (2.06–2.88)	0.65	2.70 (1.44–5.06)	0.43	3.72 (2.29–6.04)	0.08	3.69 (1.53–8.91)
Oral contraceptive use
Never	2.61 (1.92–3.54)		2.76 (2.09–3.63)		1.99 (0.74–5.34)		4.84 (2.24–10.43)		2.02 (0.46–8.91)
<1 year	2.54 (1.36–4.75)		2.35 (1.37–4.03)		4.63 (0.17–123.03)		1.47 (0.19–11.27)		15.18 (0.48–478.27)
1–1.99 years	2.99 (1.40–6.37)		3.03 (1.51–6.06)		15.72 (0.07–3522.25)		0.73 (0.09–6.29)		0.64 (0.01–43.62)
2–4.99 years	2.61 (1.55–4.39)		2.48 (1.55–3.98)		2.67 (0.20–36.47)		1.54 (0.31–7.60)		16.95 (1.17–244.76)
5–9.99 years	2.66 (1.64–4.32)		2.14 (1.37–3.35)		2.93 (0.64–13.43)		5.87 (1.45–23.76)		0.54 (0.03–8.67)
10+ years	2.49 (1.53–4.07)	1.00	1.88 (1.19–2.97)	0.74	0.76 (0.11–5.14)	0.84	6.89 (1.64–28.91)	0.33	0.32 (0.01–11.28)	0.32
Tubal ligation
Yes	2.93 (1.89–4.55)		2.47 (1.69–3.62)		2.18 (0.24–20.32)		5.48 (1.24–24.20)		2.28 (0.13–41.13)
No	2.52 (2.04–3.12)	0.54	2.46 (2.03–2.99)	0.98	2.79 (1.40–5.58)	0.84	4.05 (2.34–7.00)	0.71	5.55 (2.06–14.94)	0.57
Parity
No births	2.15 (1.38–3.36)		2.19 (1.45–3.31)		4.23 (1.07–16.78)		1.40 (0.49–3.97)		2.71 (0.49–14.92)
1 birth	3.07 (1.85–5.10)		2.60 (1.64–4.10)		4.28 (0.79–23.30)		7.07 (1.87–26.69)		3.47 (0.17–69.26)
2–3 births	2.36 (1.84–3.02)		2.29 (1.83–2.87)		2.39 (0.97–5.92)		2.71 (1.32–5.59)		2.30 (0.55–9.72)
4–5 births	4.05 (2.28–7.20)		3.52 (2.14–5.79)		5.39 (0.20–142.90)		9.03 (1.73–47.26)		19.43 (0.31–1206.17)
6+ births	1.91 (0.43–8.59)	0.40	2.04 (0.55–7.56)	0.59	—	0.86	1.58 (0.02–116.21)	0.24	–	0.82
Age
<50 years old	2.64 (1.83–3.80)		2.53 (1.77–3.60)		4.25 (1.39–12.99)		4.64 (1.85–11.61)		4.18 (0.64–27.11)
50–54 years old	2.63 (1.62–4.27)		2.11 (1.36–3.29)		1.30 (0.19–8.79)		3.31 (0.97–11.27)		2.30 (0.18–28.95)
55–59 years old	2.16 (1.41–3.31)		2.16 (1.46–3.18)		3.08 (0.60–15.75)		4.13 (1.32–12.94)		4.86 (0.80–29.46)
60–64 years old	2.61 (1.69–4.04)		2.68 (1.84–3.90)		0.91 (0.15–5.66)		1.85 (0.47–7.34)		4.44 (0.47–42.19)
65+ years old	2.63 (1.88–3.69)	0.96	2.68 (1.99–3.61)	0.84	2.95 (0.88–9.95)	0.63	2.54 (1.01–6.38)	0.80	1.28 (0.15–10.80)	0.89

↵^aOR conditioned on race/ethnicity, individual models by site; estimate derived from meta-analysis of individual site models.
↵^bP_het = heterogeneity across strata of environmental factor.