Table 3.

Association between genetic risk score and ovarian cancer among all women and by environmental factors

InvasiveSerousMucinousEndometrioidClear cell
ORa (95% CI)PhetbORa 95% CIPhetbORa 95% CIPhetbORa 95% CIPhetbORa 95% CIPhetb
All women2.56 (2.14–3.06)2.50 (2.13–2.94)2.61 (1.41–4.81)3.49 (2.18–5.59)3.11 (1.31–7.39)
Endometriosis
 Yes4.35 (2.09–9.05)6.50 (3.10–13.63)2.88 (0.06–143.62)6.86 (1.32–35.66)2.03 (0.13–30.77)
 No2.47 (2.02–3.02)0.142.31 (1.93–2.77)0.012.50 (1.24–5.01)0.943.86 (2.24–6.67)0.523.73 (1.31–10.61)0.68
First-degree family history
 Yes2.48 (0.87–7.08)3.02 (1.22–7.44)0.33 (0.00–61.92)0.22 (0.01–5.00)
 No2.51 (2.09–3.01)0.982.44 (2.06–2.88)0.652.70 (1.44–5.06)0.433.72 (2.29–6.04)0.083.69 (1.53–8.91)
Oral contraceptive use
 Never2.61 (1.92–3.54)2.76 (2.09–3.63)1.99 (0.74–5.34)4.84 (2.24–10.43)2.02 (0.46–8.91)
 <1 year2.54 (1.36–4.75)2.35 (1.37–4.03)4.63 (0.17–123.03)1.47 (0.19–11.27)15.18 (0.48–478.27)
 1–1.99 years2.99 (1.40–6.37)3.03 (1.51–6.06)15.72 (0.07–3522.25)0.73 (0.09–6.29)0.64 (0.01–43.62)
 2–4.99 years2.61 (1.55–4.39)2.48 (1.55–3.98)2.67 (0.20–36.47)1.54 (0.31–7.60)16.95 (1.17–244.76)
 5–9.99 years2.66 (1.64–4.32)2.14 (1.37–3.35)2.93 (0.64–13.43)5.87 (1.45–23.76)0.54 (0.03–8.67)
 10+ years2.49 (1.53–4.07)1.001.88 (1.19–2.97)0.740.76 (0.11–5.14)0.846.89 (1.64–28.91)0.330.32 (0.01–11.28)0.32
Tubal ligation
 Yes2.93 (1.89–4.55)2.47 (1.69–3.62)2.18 (0.24–20.32)5.48 (1.24–24.20)2.28 (0.13–41.13)
 No2.52 (2.04–3.12)0.542.46 (2.03–2.99)0.982.79 (1.40–5.58)0.844.05 (2.34–7.00)0.715.55 (2.06–14.94)0.57
Parity
 No births2.15 (1.38–3.36)2.19 (1.45–3.31)4.23 (1.07–16.78)1.40 (0.49–3.97)2.71 (0.49–14.92)
 1 birth3.07 (1.85–5.10)2.60 (1.64–4.10)4.28 (0.79–23.30)7.07 (1.87–26.69)3.47 (0.17–69.26)
 2–3 births2.36 (1.84–3.02)2.29 (1.83–2.87)2.39 (0.97–5.92)2.71 (1.32–5.59)2.30 (0.55–9.72)
 4–5 births4.05 (2.28–7.20)3.52 (2.14–5.79)5.39 (0.20–142.90)9.03 (1.73–47.26)19.43 (0.31–1206.17)
 6+ births1.91 (0.43–8.59)0.402.04 (0.55–7.56)0.590.861.58 (0.02–116.21)0.240.82
Age
 <50 years old2.64 (1.83–3.80)2.53 (1.77–3.60)4.25 (1.39–12.99)4.64 (1.85–11.61)4.18 (0.64–27.11)
 50–54 years old2.63 (1.62–4.27)2.11 (1.36–3.29)1.30 (0.19–8.79)3.31 (0.97–11.27)2.30 (0.18–28.95)
 55–59 years old2.16 (1.41–3.31)2.16 (1.46–3.18)3.08 (0.60–15.75)4.13 (1.32–12.94)4.86 (0.80–29.46)
 60–64 years old2.61 (1.69–4.04)2.68 (1.84–3.90)0.91 (0.15–5.66)1.85 (0.47–7.34)4.44 (0.47–42.19)
 65+ years old2.63 (1.88–3.69)0.962.68 (1.99–3.61)0.842.95 (0.88–9.95)0.632.54 (1.01–6.38)0.801.28 (0.15–10.80)0.89
  • aOR conditioned on race/ethnicity, individual models by site; estimate derived from meta-analysis of individual site models.

  • bPhet = heterogeneity across strata of environmental factor.