Table 2.

ORs for risk of RCC in relation to leukocyte telomere length, overall and stratified by sex, age, and time from blood collection to case diagnosisa

AnalysisFirst quartileSecond quartileThird quartileFourth quartilePtrendb
Overall
 Cases/controls51/10349/10264/10345/102
 Unadjusted OR (95% CI)c1.0 (Ref.)0.9 (0.6–1.5)1.2 (0.8–1.9)0.9 (0.5–1.5)0.6
 Adjusted OR (95% CI)d1.0 (Ref.)0.9 (0.6–1.5)1.1 (0.7–1.7)0.8 (0.5–1.5)0.6
By sexe
 Men
  Cases/controls39/8433/6849/6726/69
  Unadjusted OR (95% CI)c1.0 (Ref.)1.0 (0.6–1.8)1.5 (0.9–2.6)0.8 (0.4–1.5)0.4
  Adjusted OR (95% CI)d1.0 (Ref.)1.0 (0.6–1.8)1.3 (0.8–2.4)0.8 (0.4–1.7)0.6
 Women
  Cases/controls12/1916/3415/3619/33
  Unadjusted OR (95% CI)c1.0 (Ref.)0.7 (0.3–1.9)0.7 (0.3–1.7)0.9 (0.3–2.5)0.9
  Adjusted OR (95% CI)d1.0 (Ref.)0.8 (0.3–2.2)0.5 (0.2–1.4)0.8 (0.2–2.4)0.7
By age at baselinee
 55–64 y
  Cases/controls33/6332/7342/6329/69
  Unadjusted OR (95% CI)c1.0 (Ref.)0.8 (0.5–1.5)1.2 (0.7–2.2)0.8 (0.4–1.5)0.6
  Adjusted OR (95% CI)d1.0 (Ref.)0.8 (0.4–1.5)1.0 (0.6–1.9)0.8 (0.4–1.6)0.6
 65–74 y
  Cases/controls18/4017/2922/4016/33
  Unadjusted OR (95% CI)c1.0 (Ref.)1.3 (0.5–3.0)1.2 (0.5–2.7)1.0 (0.4–2.6)0.9
  Adjusted OR (95% CI)d1.0 (Ref.)1.3 (0.5–3.1)1.1 (0.5–2.6)1.0 (0.4–2.6)0.8
By time from blood collection to case diagnosis
 <6y to RCC diagnosis
  Cases/controls24/5021/4428/5020/39
  Unadjusted OR (95% CI)c1.0 (Ref.)1.0 (0.5–2.0)1.2 (0.6–2.4)1.1 (0.5–2.4)0.8
  Adjusted OR (95% CI)d1.0 (Ref.)0.9 (0.4–1.9)1.0 (0.5–2.1)1.0 (0.4–2.4)>0.9
 ≥6y to RCC diagnosis
  Cases/controls27/5328/5836/5325/63
  Unadjusted OR (95% CI)c1.0 (Ref.)0.9 (0.5–1.7)1.2 (0.6–2.3)0.7 (0.3–1.5)0.3
  Adjusted OR (95% CI)d1.0 (Ref.)0.9 (0.4–1.7)1.0 (0.5–2.0)0.7 (0.3–1.6)0.5
  • aAnalyses were conducted using conditional logistic regression models. Quartiles of telomere length were assigned on the basis of the distribution among controls as follows: first quartile, ≤0.97; second quartile, 0.98–1.15; third quartile, 1.16–1.50; fourth quartile, ≥1.51.

  • bTests for trend were conducted by assigning the within-category median for each quartile and analyzing these data as a continuous variable.

  • cConditioned on matched sets.

  • dConditioned on matched sets and adjusted for history of hypertension, smoking status, and BMI.

  • ePinteraction ≥ 0.4, likelihood ratio test.