Table 2.

ORs and 95% CIs for pancreatic cancer according to inflammatory plasma markers

Quintiles of inflammatory plasma markers
12345PtrendaOne-unit increase
CRP
 Levels, mg/L<0.50.5–1.11.2–2.12.2–4.2≥4.3
 No. of cases791018695109470
 No. of controls2152192202202201094
 Base modelb1.01.23 (0.85–1.76)1.00 (0.69–1.45)1.16 (0.80–1.68)1.27 (0.88–1.83)0.311.00 (0.98–1.02)
 Multivariatec1.01.18 (0.81–1.71)0.97 (0.65–1.42)1.09 (0.73–1.62)1.10 (0.74–1.63)0.810.99 (0.98–1.01)
IL-6
 Levels, pg/mL<0.70.7–1.01.1–1.41.5–2.1≥2.2
 No. of cases836877109125462
 No. of controls2122112112122131059
 Base modelb1.00.81 (0.56–1.19)0.88 (0.60–1.28)1.24 (0.85–1.80)1.38 (0.96–1.98)0.011.02 (1.00–1.05)
 Multivariatec1.00.82 (0.56–1.21)0.81 (0.55–1.21)1.14 (0.77–1.69)1.19 (0.81–1.76)0.081.01 (0.99–1.04)
TNF-αR2
 Levels, mg/mL<2.12.1–2.42.5–2.82.9–3.4≥3.5
 No. of cases899582101103470
 No. of controls2182192192192191094
 Base modelb1.01.05 (0.74–1.49)0.89 (0.61–1.29)1.03 (0.72–1.48)1.02 (0.69–1.49)0.930.98 (0.88–1.10)
 Multivariatec1.00.96 (0.67–1.39)0.79 (0.54–1.17)0.92 (0.63–1.34)0.88 (0.58–1.33)0.570.92 (0.82–1.04)
  • aP values were calculated by the Wald test of a score variable that contained median values of quintiles.

  • bORs and 95% CI were estimated by conditional logistic regression conditioned on the matching factors including year of birth, prospective cohort (HPFS, NHS, PHS I, WHI, WHS, which concurrently matched on sex), smoking status (never, past, current), fasting status (fasting, nonfasting), and month of blood draw.

  • cBase model further adjusted for race (White, Black, other), history of diabetes mellitus (yes, no), BMI (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), physical activity (quartiles), current multivitamin use (yes, no), plasma 25(OH)D levels (quartiles), and plasma C-peptide levels (quartiles).