Table 2.

Association between each SNP and invasive ovarian cancer among all women and by environmental factors

	rs3814113		rs2072590		rs2665390		rs10088218		rs8170		rs9303542
	OR^a (95% CI)	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b	OR^a 95% CI	P_het^b
Main effect: Previously published result (11–13)	0.82 (0.79–0.86)		1.16 (1.12–1.21)		1.19 (1.11–1.27)		0.84 (0.80–0.89)		1.12 (1.07–1.17)		1.11 (1.06–1.16)
Main effect: Current report^c	0.82 (0.77–0.88)		1.13 (1.07–1.19)		1.25 (1.14–1.38)		0.84 (0.78–0.91)		1.07 (1.01–1.14)		1.11 (1.04–1.17)
Endometriosis
Yes	0.84 (0.60–1.16)		1.45 (1.14–1.85)		1.73 (1.10–2.73)		0.78 (0.61–1.01)		1.06 (0.82–1.36)		0.93 (0.71–1.23)
No	0.83 (0.76–0.91)	0.98	1.12 (1.06–1.19)	0.05	1.23 (1.10–1.37)	0.15	0.84 (0.78–0.90)	0.60	1.12 (1.05–1.19)	0.69	1.05 (0.98–1.13)	0.41
First-degree family history
Yes	0.67 (0.46–0.99)		1.01 (0.73–1.38)		0.98 (0.54–1.77)		0.74 (0.47–1.16)		1.07 (1.00–1.15)		1.10 (1.04–1.17)
No	0.83 (0.78–0.88)	0.30	1.13 (1.07–1.19)	0.49	1.25 (1.13–1.37)	0.43	0.84 (0.78–0.92)	0.56	0.92 (0.65–1.32)	0.42	1.08 (0.75–1.57)	0.93
Oral contraceptive use
Never	0.77 (0.70–0.86)		1.06 (0.96–1.16)		1.22 (1.03–1.43)		0.84 (0.73–0.96)		1.10 (0.99–1.23)		1.11 (1.00–1.22)
<1 year	0.82 (0.66–1.02)		1.18 (0.97–1.44)		1.24 (0.88–1.75)		0.79 (0.59–1.04)		0.83 (0.67–1.04)		1.21 (0.99–1.48)
1–1.99 years	1.03 (0.80–1.33)		1.31 (1.03–1.68)		1.68 (1.05–2.67)		0.86 (0.60–1.25)		1.19 (0.89–1.60)		1.27 (0.98–1.65)
2–4.99 years	0.80 (0.67–0.96)		1.15 (0.99–1.34)		1.36 (1.03–1.79)		0.73 (0.58–0.93)		1.00 (0.83–1.20)		1.00 (0.85–1.18)
5–9.99 years	0.87 (0.74–1.03)		1.10 (0.94–1.27)		1.31 (1.01–1.69)		0.80 (0.64–0.99)		1.13 (0.94–1.36)		1.16 (1.00–1.35)
10+ years	0.92 (0.78–1.09)	0.27	1.19 (1.02–1.38)	0.52	1.41 (1.08–1.83)	0.81	0.98 (0.78–1.22)	0.63	1.11 (0.93–1.33)	0.24	1.16 (0.99–1.36)	0.56
Tubal ligation
Yes	0.91 (0.78–1.06)		1.22 (1.06–1.39)		1.23 (0.97–1.54)		0.74 (0.60–0.91)		1.04 (0.97–1.13)		1.13 (1.05–1.20)
No	0.81 (0.76–0.87)	0.21	1.10 (1.03–1.17)	0.21	1.32 (1.18–1.49)	0.55	0.86 (0.78–0.95)	0.19	1.22 (1.04–1.43)	0.09	1.05 (0.92–1.21)	0.42
Parity
No births	0.82 (0.70–0.96)		1.07 (0.93–1.24)		1.20 (0.94–1.53)		0.83 (0.68–1.02)		1.08 (0.91–1.28)		1.08 (0.93–1.26)
1 birth	0.78 (0.66–0.93)		1.15 (0.99–1.33)		1.46 (1.10–1.93)		0.87 (0.69–1.10)		1.05 (0.88–1.26)		1.07 (0.91–1.26)
2–3 births	0.86 (0.79–0.94)		1.12 (1.04–1.21)		1.21 (1.05–1.38)		0.84 (0.75–0.94)		1.11 (1.01–1.22)		1.11 (1.03–1.21)
4–5 births	0.74 (0.61–0.89)		1.25 (1.04–1.49)		1.30 (0.96–1.74)		0.68 (0.52–0.89)		0.96 (0.78–1.17)		1.09 (0.91–1.30)
6+ births	1.23 (0.71–2.14)	0.31	1.28 (0.72–2.27)	0.31	2.26 (0.98–5.19)	0.48	0.80 (0.38–1.69)	0.68	0.74 (0.43–1.30)	0.48	1.09 (0.64–1.87)	0.99
Age
<50 years old	0.83 (0.73–0.94)		1.20 (1.07–1.35)		1.33 (1.08–1.64)		0.82 (0.70–0.97)		0.96 (0.83–1.10)		1.12 (1.00–1.26)
50–54 years old	0.83 (0.71–0.98)		1.12 (0.97–1.30)		1.25 (0.96–1.63)		0.94 (0.75–1.17)		1.07 (0.89–1.28)		1.21 (1.04–1.40)
55–59 years old	0.77 (0.67–0.90)		1.07 (0.94–1.23)		1.17 (0.93–1.47)		0.94 (0.78–1.14)		1.18 (1.01–1.39)		1.03 (0.89–1.18)
60–64 years old	0.80 (0.68–0.93)		1.12 (0.98–1.27)		1.38 (1.10–1.74)		0.84 (0.69–1.02)		1.13 (0.97–1.32)		0.99 (0.86–1.14)
65+ years old	0.87 (0.78–0.98)	0.77	1.11 (1.00–1.23)	0.78	1.25 (1.04–1.50)	0.87	0.78 (0.67–0.91)	0.52	1.09 (0.97–1.22)	0.34	1.17 (1.05–1.30)	0.20

↵^aOR conditioned on race/ethnicity, individual models by site; estimate derived from meta-analysis of individual site models.
↵^bP_het = heterogeneity across strata of environmental factor.
↵^cMain effect of genotype based on a log-additive model.