Table 2.

Association between each SNP and invasive ovarian cancer among all women and by environmental factors

rs3814113rs2072590rs2665390rs10088218rs8170rs9303542
ORa (95% CI)PhetbORa 95% CIPhetbORa 95% CIPhetbORa 95% CIPhetbORa 95% CIPhetbORa 95% CIPhetb
Main effect: Previously published result (11–13)0.82 (0.79–0.86)1.16 (1.12–1.21)1.19 (1.11–1.27)0.84 (0.80–0.89)1.12 (1.07–1.17)1.11 (1.06–1.16)
Main effect: Current reportc0.82 (0.77–0.88)1.13 (1.07–1.19)1.25 (1.14–1.38)0.84 (0.78–0.91)1.07 (1.01–1.14)1.11 (1.04–1.17)
Endometriosis
 Yes0.84 (0.60–1.16)1.45 (1.14–1.85)1.73 (1.10–2.73)0.78 (0.61–1.01)1.06 (0.82–1.36)0.93 (0.71–1.23)
 No0.83 (0.76–0.91)0.981.12 (1.06–1.19)0.051.23 (1.10–1.37)0.150.84 (0.78–0.90)0.601.12 (1.05–1.19)0.691.05 (0.98–1.13)0.41
First-degree family history
 Yes0.67 (0.46–0.99)1.01 (0.73–1.38)0.98 (0.54–1.77)0.74 (0.47–1.16)1.07 (1.00–1.15)1.10 (1.04–1.17)
 No0.83 (0.78–0.88)0.301.13 (1.07–1.19)0.491.25 (1.13–1.37)0.430.84 (0.78–0.92)0.560.92 (0.65–1.32)0.421.08 (0.75–1.57)0.93
Oral contraceptive use
 Never0.77 (0.70–0.86)1.06 (0.96–1.16)1.22 (1.03–1.43)0.84 (0.73–0.96)1.10 (0.99–1.23)1.11 (1.00–1.22)
 <1 year0.82 (0.66–1.02)1.18 (0.97–1.44)1.24 (0.88–1.75)0.79 (0.59–1.04)0.83 (0.67–1.04)1.21 (0.99–1.48)
 1–1.99 years1.03 (0.80–1.33)1.31 (1.03–1.68)1.68 (1.05–2.67)0.86 (0.60–1.25)1.19 (0.89–1.60)1.27 (0.98–1.65)
 2–4.99 years0.80 (0.67–0.96)1.15 (0.99–1.34)1.36 (1.03–1.79)0.73 (0.58–0.93)1.00 (0.83–1.20)1.00 (0.85–1.18)
 5–9.99 years0.87 (0.74–1.03)1.10 (0.94–1.27)1.31 (1.01–1.69)0.80 (0.64–0.99)1.13 (0.94–1.36)1.16 (1.00–1.35)
 10+ years0.92 (0.78–1.09)0.271.19 (1.02–1.38)0.521.41 (1.08–1.83)0.810.98 (0.78–1.22)0.631.11 (0.93–1.33)0.241.16 (0.99–1.36)0.56
Tubal ligation
 Yes0.91 (0.78–1.06)1.22 (1.06–1.39)1.23 (0.97–1.54)0.74 (0.60–0.91)1.04 (0.97–1.13)1.13 (1.05–1.20)
 No0.81 (0.76–0.87)0.211.10 (1.03–1.17)0.211.32 (1.18–1.49)0.550.86 (0.78–0.95)0.191.22 (1.04–1.43)0.091.05 (0.92–1.21)0.42
Parity
 No births0.82 (0.70–0.96)1.07 (0.93–1.24)1.20 (0.94–1.53)0.83 (0.68–1.02)1.08 (0.91–1.28)1.08 (0.93–1.26)
 1 birth0.78 (0.66–0.93)1.15 (0.99–1.33)1.46 (1.10–1.93)0.87 (0.69–1.10)1.05 (0.88–1.26)1.07 (0.91–1.26)
 2–3 births0.86 (0.79–0.94)1.12 (1.04–1.21)1.21 (1.05–1.38)0.84 (0.75–0.94)1.11 (1.01–1.22)1.11 (1.03–1.21)
 4–5 births0.74 (0.61–0.89)1.25 (1.04–1.49)1.30 (0.96–1.74)0.68 (0.52–0.89)0.96 (0.78–1.17)1.09 (0.91–1.30)
 6+ births1.23 (0.71–2.14)0.311.28 (0.72–2.27)0.312.26 (0.98–5.19)0.480.80 (0.38–1.69)0.680.74 (0.43–1.30)0.481.09 (0.64–1.87)0.99
Age
 <50 years old0.83 (0.73–0.94)1.20 (1.07–1.35)1.33 (1.08–1.64)0.82 (0.70–0.97)0.96 (0.83–1.10)1.12 (1.00–1.26)
 50–54 years old0.83 (0.71–0.98)1.12 (0.97–1.30)1.25 (0.96–1.63)0.94 (0.75–1.17)1.07 (0.89–1.28)1.21 (1.04–1.40)
 55–59 years old0.77 (0.67–0.90)1.07 (0.94–1.23)1.17 (0.93–1.47)0.94 (0.78–1.14)1.18 (1.01–1.39)1.03 (0.89–1.18)
 60–64 years old0.80 (0.68–0.93)1.12 (0.98–1.27)1.38 (1.10–1.74)0.84 (0.69–1.02)1.13 (0.97–1.32)0.99 (0.86–1.14)
 65+ years old0.87 (0.78–0.98)0.771.11 (1.00–1.23)0.781.25 (1.04–1.50)0.870.78 (0.67–0.91)0.521.09 (0.97–1.22)0.341.17 (1.05–1.30)0.20
  • aOR conditioned on race/ethnicity, individual models by site; estimate derived from meta-analysis of individual site models.

  • bPhet = heterogeneity across strata of environmental factor.

  • cMain effect of genotype based on a log-additive model.