Table 1.

USPSTF increased-risk family history patterns (1)

Non-Ashkenazi Jewish Women:
  • 1. Two first-degree relatives with breast cancer, 1 of whom received the diagnosis at age 50 years or younger

  • 2. A combination of 3 or more first- or second-degree relatives with breast cancer regardless of age at diagnosis

  • 3. A combination of both breast and ovarian cancer among first- and second-degree relatives

  • 4. A first-degree relative with bilateral breast cancer

  • 5. A combination of 2 or more first- or second-degree relatives with ovarian cancer regardless of age at diagnosis

  • 6. A first- or second-degree relative with both breast and ovarian cancer at any age

  • 7. A history of breast cancer in a male relative

Women of Ashkenazi Jewish Heritage:
  • 8. Any first-degree relative (or 2 second-degree relatives on the same side of the family) with breast or ovarian cancer