Table 2.

Associations between selected SNPs and PDAC risk and patients survival

Risk analysisSurvival analysis
SNPGenotypesCasesaControlsaOR (95% CI)bPvaluePtrendTestSubjectsaDeathsaHR (95% CI)cPvalue
rs12413624TT3928820.7528Per allele1,0918870.95 (0.86–1.06)0.38
AT61613931.02 (0.87–1.19)0.832TT vs. AT0.99 (0.83–1.19)0.91
AA2695851.05 (0.86–1.28)0.626TT vs. AA0.90 (0.72–1.12)0.35
AT + AA1.03 (0.88–1.19)0.727TT vs. (AT + AA)0.96 (0.81–1.14)0.63
rs1547374AA5261,2790.1864Per allele1,0948950.94 (0.83–1.06)0.29
AG6111,2651.16 (1.00–1.35)0.043AA vs. AG0.89 (0.75–1.05)0.17
GG1443351.05 (0.83–1.32)0.685AA vs. GG0.92 (0.71–1.21)0.56
AG + GG1.14 (0.99–1.31)0.067AA vs. (AG + GG)0.90 (0.76–1.05)0.18
rs372883AA3447750.952Per allele1,0598600.90 (0.80–1.00)0.06
AG6131,4460.97 (0.82–1.14)0.7AA vs. AG0.90 (0.74–1.10)0.31
GG2886500.98 (0.80–1.19)0.83AA vs. GG0.81 (0.65–1.01)0.06
AG + GG0.97 (0.83–1.14)0.715AA vs. (AG + GG)0.87 (0.72–1.04)0.13
rs5768709AA5109510.0378Per allele1,0838830.97 (0.86–1.09)0.57
AG5801,2210.92 (0.79–1.07)0.277AA vs. AG0.98 (0.82–1.16)0.79
GG1804080.86 (0.69–1.07)0.166AA vs. GG0.93 (0.73–1.19)0.56
AG + GG0.90 (0.78–1.04)0.17AA vs. (AG + GG)0.96 (0.82–1.14)0.67
rs6464375GG11242,5220.3589Per allele1,1119041.26 (1.00–1.58)0.05
AG1693531.13 (0.92–1.38)0.258GG vs. AG1.22 (0.96–1.55)0.10
AA691.83 (0.62–5.36)0.271GG vs. AA3.26 (0.80–13.21)0.10
AG + AA1.14 (0.93–1.40)0.199GG vs. (AG + AA)1.24 (0.98–1.57)0.07
rs708224GG4499190.7476Per allele1,1049001.11 (0.99–1.23)0.08
AG5981,3780.90 (0.77–1.05)0.189GG vs. AG1.09 (0.91–1.30)0.37
AA2465011.07 (0.87–1.30)0.524GG vs. AA1.23 (0.98–1.53)0.07
AG + AA0.94 (0.82–1.09)0.441GG vs. (AG + AA)1.12 (0.95–1.33)0.17
rs9502893AA4528990.5069Per allele1,0848801.00 (0.90–1.11)0.98
AG5551,3380.84 (0.71–0.98)0.027AA vs. AG0.98 (0.79–1.21)0.85
GG2655360.98 (0.81–1.19)0.861AA vs. GG1.07 (0.90–1.26)0.44
AG + GG0.88 (0.76–1.02)0.087AA vs. (AG + GG)1.13 (0.94–1.35)0.20
  • aNumbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to 2 additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.

  • bAll analyses were adjusted for age, gender, and nationality. Significant associations (P < 0.05) are reported in bold.

  • cAll analyses were adjusted for age, gender, TNM stage, and nationality.