Table 3.

FGFR2 haplotypes in data from the BWHS, 1,199 breast cancer cases and 1,948 controls

Haplotype frequenciesOR (95% CI)
RegionAll casesER+/PR+ER−/PR−ControlsAll casesER+/PR+ER−/PR−
10q26Index 1Index 2Index 3
rs2981579rs1219648rs2981582
CAG0.360.330.350.371.00 (ref)1.00 (ref)1.00 (ref)
CGG0.020.010.020.020.81 (0.50–1.33)0.38 (0.11–1.31)1.09 (0.45–2.66)
TAG0.080.090.070.080.91 (0.72–1.16)1.17 (0.79–1.74)0.87 (0.53–1.42)
TAA0.130.130.120.121.02 (0.84–1.25)1.19 (0.84–1.68)1.07 (0.72–1.58)
TGG0.040.050.050.051.02 (0.74–1.40)1.27 (0.76–2.15)1.08 (0.59–1.98)
TGA0.370.390.380.351.05 (0.91–1.20)1.25 (0.99–1.59)1.15 (0.88–1.50)

NOTE: ORs adjusted for age, geographic region of residence, and country of birth. Alleles in bold indicate risk allele for that SNP. Pairwise r2: rs2981579/rs1219648 0.34; rs2981579/rs2981582 0.54; and rs1219648/rs2981582 0.37.