Table 4.

Global CaSR association and individual SNP associations (OR and 95% CI) for lethal prostate cancer by total calcium intakea

Low calcium intake (n = 74 lethal cases)High calcium intake (n = 39 lethal cases)
SNP name (minor, major allele)OR (95% CI)POR (95% CI)PP
rs9820206(A,G)0.77 (0.50–1.17)0.221.08 (0.61–1.89)0.800.34
rs6438705(A,G)0.66 (0.39–1.10)0.110.64 (0.31–1.30)0.220.94
rs13083990(C,T)0.68 (0.46–1.01)0.050.60 (0.34–1.05)0.070.69
rs4678173(A,C)1.27 (0.90–1.78)0.171.12 (0.69–1.81)0.660.63
rs1979869(T,C)0.65 (0.42–1.01)0.050.91 (0.51–1.63)0.760.36
rs2270916(C,T)1.54 (0.99–2.41)0.061.54 (0.86–2.74)0.141.00
rs16832787(A,G)1.29 (0.86–1.92)0.221.03 (0.56–1.89)0.940.59
rs2134223(G,A)0.96 (0.59–1.56)0.851.02 (0.52–1.97)0.960.90
rs4638910(G,T)0.98 (0.59–1.62)0.940.81 (0.38–1.71)0.580.72
rs1501900(T,A)1.04 (0.69–1.59)0.851.39 (0.81–2.39)0.230.43
rs1393198(C,T)1.14 (0.69–1.88)0.610.64 (0.29–1.40)0.260.22
rs7613238(G,A)1.22 (0.86–1.73)0.250.91 (0.56–1.47)0.690.30
rs7637874(T,C)1.62 (1.11–2.35)0.010.63 (0.35–1.15)0.130.008
rs7648041(T,C)1.12 (0.76–1.64)0.560.67 (0.38–1.18)0.170.13
rs7630625(A,G)0.90 (0.62–1.30)0.571.21 (0.74–1.98)0.450.33
rs1801725(T,G)0.63 (0.38–1.05)0.080.88 (0.43–1.83)0.740.51
rs1042636(G,A)0.86 (0.45–1.65)0.650.62 (0.22–1.75)0.370.60
rs1801726(G,C)1.47 (0.75–2.89)0.261.18 (0.33–4.18)0.800.76
Kernel machine result0.050.37
  • aLow calcium intake: 829 controls; high calcium intake: 415 controls.