Table 3.

Global CaSR association and individual SNP associations (OR and 95% CI) for lethal prostate cancer by plasma 25(OH)D levelsa

Low plasma 25(OH)D (n = 73 lethal cases)High plasma 25(OH)D (n = 40 lethal cases)
SNP name (minor, major allele)OR (95% CI)POR (95% CI)PP interaction
rs9820206(A,G)0.68 (0.43–1.07)0.091.20 (0.72–2.01)0.490.04
rs6438705(A,G)0.62 (0.37–1.06)0.080.67 (0.33–1.36)0.270.68
rs13083990(C,T)0.60 (0.40–0.90)0.010.74 (0.44–1.26)0.270.91
rs4678173(A,C)1.01 (0.71–1.45)0.941.57 (1.00–2.47)0.050.32
rs1979869(T,C)0.59 (0.38–0.94)0.030.98 (0.56–1.70)0.930.09
rs2270916(C,T)2.03 (1.32–3.11)0.0010.89 (0.45–1.75)0.730.02
rs16832787(A,G)1.31 (0.86–2.00)0.221.08 (0.62–1.88)0.790.52
rs2134223(G,A)0.87 (0.53–1.43)0.591.10 (0.57–2.12)0.780.39
rs4638910(G,T)1.19 (0.72–1.97)0.500.64 (0.30–1.37)0.250.47
rs1501900(T,A)1.06 (0.69–1.61)0.801.31 (0.77–2.23)0.320.11
rs1393198(C,T)0.89 (0.52–1.53)0.681.05 (0.53–2.08)0.890.73
rs7613238(G,A)1.35 (0.94–1.93)0.100.81 (0.50–1.29)0.370.19
rs7637874(T,C)1.44 (0.98–2.13)0.060.87 (0.50–1.50)0.610.35
rs7648041(T,C)0.99 (0.67–1.46)0.950.83 (0.48–1.42)0.490.29
rs7630625(A,G)1.06 (0.73–1.55)0.760.93 (0.57–1.51)0.760.62
rs1801725(T,G)0.54 (0.31–0.95)0.030.98 (0.52–1.87)0.960.14
rs1042636(G,A)0.80 (0.40–1.60)0.540.75 (0.30–1.88)0.540.40
rs1801726(G,C)1.14 (0.55–2.37)0.731.99 (0.72–5.53)0.180.24
Kernel machine result0.0090.56
  • aLow plasma 25(OH)D: 614 controls; high plasma 25(OH)D: 620 controls.