Association between mammographic density measures and serum sex-hormone levels
Percentage density | Absolute dense area | Nondense area | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Covariates in model | β | SE | P value | β | SE | P value | β | SE | P value | |
Serum estradiol (n = 671) | Age and batch | −0.50 | 0.08 | <0.001 | −57.9 | 17.8 | 0.001 | 228.6 | 28.7 | <0.001 |
+BMIa | −0.15 | 0.08 | 0.047 | −39.3 | 19.9 | 0.049 | 15.4 | 20.8 | 0.46 | |
Serum testosterone (n = 682) | Age and batch | −0.32 | 0.09 | <0.001 | −49.2 | 22.2 | 0.03 | 125.2 | 31.7 | <0.001 |
+BMIa | −0.16 | 0.08 | 0.064 | −38.6 | 22.4 | 0.09 | 31.4 | 22.8 | 0.17 | |
Serum SHBG (n = 682) | Age and batch | 0.84 | 0.14 | <0.001 | 56.2 | 32.3 | 0.08 | −435.9 | 45.9 | <0.001 |
+BMIa | 0.19 | 0.15 | 0.19 | 7.82 | 36.7 | 0.83 | −68.1 | 41.8 | 0.10 |
↵aBMI was added to the model that adjusts for age and batch.