Influence of quercetin-rich food intake (T3 vs. T1) on family of functionala miR, stratified by histology and smoking status
AD | SQs | ||||
---|---|---|---|---|---|
Former | Current | Former | Current | ||
Family Function | miRNA members | Pa | Pa | Pa | Pa |
Let-7 family | hsa-miR-let-7a | P < 0.001 | P = 0.426 | P = 0.366 | P = 0.988 |
Tumor suppressor | hsa-miR-let-7b | ||||
hsa-miR-let-7c | |||||
hsa-miR-let-7d | |||||
hsa-miR-let-7e | |||||
hsa-miR-let-7f | |||||
hsa-miR-let-7g | |||||
hsa-miR-let-7i | |||||
hsa-miR-98 | |||||
hsa-miR-202 | |||||
miR-146 family | hsa-miR-146a | P = 0.002 | P = 0.092 | P = 0.753 | P = 0.222 |
Tumor growth and invasion | hsa-miR-146b | ||||
miR-26 family | hsa-miR-26a | P = 0.010 | P = 0.623 | P = 0.588 | P = 0.664 |
Apoptosis | hsa-miR-26b | ||||
miR-17 family | hsa-miR-20a | P = 0.031 | P = 0.943 | P = 0.766 | P = 0.283 |
Tumor progression | hsa-miR-20b | ||||
hsa-miR-106a | |||||
hsa-miR-106b | |||||
hsa-miR-17-5p | |||||
hsa-miR-93 | |||||
miR-29 family | hsa-miR-29a | P = 0.064 | P = 0.373 | P = 0.886 | P = 0.137 |
DNA methylation | hsa-miR-29b | ||||
hsa-miR-29c | |||||
miR-18 family | hsa-miR-18a | P = 0.705 | P = 0.220 | P = 0.156 | P = 0.392 |
Tumor progression | hsa-miR-18b | ||||
miR-34 family | hsa-miR-34a | P = 0.142 | P = 0.649 | P = 0.275 | P = 0.568 |
Tumor suppressor | hsa-miR-34c | ||||
miR-19 family | hsa-miR-19a | P = 0.072 | P = 0.991 | P = 0.608 | P = 0.103 |
Tumor progression | hsa-miR-19b | ||||
miR-15/16 family | hsa-miR-503 | P = 0.286 | P = 0.073 | P = 0.307 | P = 0.763 |
Apoptosis | hsa-miR-15a | ||||
hsa-miR-16 | |||||
hsa-miR-195 | |||||
hsa-miR-424 |
NOTE: Only results of miR families that had at least 1 miR that were significant at P < 0.05 from individual-based miR analyses (Table 2); bolded P values indicated results that remained significant after Bonferroni correction for multiple comparisons. Models adjusted for age, sex, BMI, non–quercetin-rich fruits and vegetables, red/processed meat, alcohol, and cigarette pack years.
*P value based on FCS as described in the Materials and Methods section.
↵aRefer to Supplementary Table S5 for more detailed functions.