Table 4.

Influence of quercetin-rich food intake (T3 vs. T1) on family of functionala miR, stratified by histology and smoking status

ADSQs
FormerCurrentFormerCurrent
Family FunctionmiRNA membersPaPaPaPa
Let-7 familyhsa-miR-let-7aP < 0.001P = 0.426P = 0.366P = 0.988
Tumor suppressorhsa-miR-let-7b
hsa-miR-let-7c
hsa-miR-let-7d
hsa-miR-let-7e
hsa-miR-let-7f
hsa-miR-let-7g
hsa-miR-let-7i
hsa-miR-98
hsa-miR-202
miR-146 familyhsa-miR-146aP = 0.002P = 0.092P = 0.753P = 0.222
Tumor growth and invasionhsa-miR-146b
miR-26 familyhsa-miR-26aP = 0.010P = 0.623P = 0.588P = 0.664
Apoptosishsa-miR-26b
miR-17 familyhsa-miR-20aP = 0.031P = 0.943P = 0.766P = 0.283
Tumor progressionhsa-miR-20b
hsa-miR-106a
hsa-miR-106b
hsa-miR-17-5p
hsa-miR-93
miR-29 familyhsa-miR-29aP = 0.064P = 0.373P = 0.886P = 0.137
DNA methylationhsa-miR-29b
hsa-miR-29c
miR-18 familyhsa-miR-18aP = 0.705P = 0.220P = 0.156P = 0.392
Tumor progressionhsa-miR-18b
miR-34 familyhsa-miR-34aP = 0.142P = 0.649P = 0.275P = 0.568
Tumor suppressorhsa-miR-34c
miR-19 familyhsa-miR-19aP = 0.072P = 0.991P = 0.608P = 0.103
Tumor progressionhsa-miR-19b
miR-15/16 familyhsa-miR-503P = 0.286P = 0.073P = 0.307P = 0.763
Apoptosishsa-miR-15a
hsa-miR-16
hsa-miR-195
hsa-miR-424

NOTE: Only results of miR families that had at least 1 miR that were significant at P < 0.05 from individual-based miR analyses (Table 2); bolded P values indicated results that remained significant after Bonferroni correction for multiple comparisons. Models adjusted for age, sex, BMI, non–quercetin-rich fruits and vegetables, red/processed meat, alcohol, and cigarette pack years.

*P value based on FCS as described in the Materials and Methods section.

  • ↵aRefer to Supplementary Table S5 for more detailed functions.